Ultrasmall Iridium Nanoparticles as Efficient Peroxidase Mimics for Colorimetric Bioassays
Ultrasmall Iridium Nanoparticles as Efficient Peroxidase Mimics for Colorimetric Bioassays
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DOI：
10.1021/acsanm.2c01226
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发表时间：
2022-05
影响因子：
5.9
通讯作者：
Zheng Xi;Weiwei Gao;Alexander Biby;Arden Floyd;Xiaohu Xia
中科院分区：
文献类型：
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作者：
Zheng Xi;Weiwei Gao;Alexander Biby;Arden Floyd;Xiaohu Xia
：在这项工作中，我们报告了一个过氧化物酶模拟物组成的铱（Ir）纳米粒子的平均尺寸只有1.1 nm，耦合到钨低价氧化物（WO 2.72）纳米棒作为支持。这种过氧化物酶模拟物的比表面积催化效率高达1.5 × 104 s-1 nm-2，优于大多数现有的贵金属过氧化物酶模拟物。作为概念验证演示，过氧化物酶模拟物被应用于癌胚抗原（癌症生物标志物）和黄曲霉毒素B1（一种强致癌物）的比色免疫测定，与传统的基于酶的测定相比，其提供了显著增强的检测灵敏度。
: In this work, we report a peroxidase mimic composed of iridium (Ir) nanoparticles with an average size of only 1.1 nm that are coupled to a tungsten suboxide (WO 2.72 ) nanorod as support. Such a peroxidase mimic exhibited an area-specific catalytic efficiency as high as 1.5 × 10 4 s -1 nm -2 , outperforming most existing peroxidase mimics of noble metals. As proof-of-concept demonstrations, the peroxidase mimic was applied to colorimetric immunoassays of carcinoembryonic antigen (a cancer biomarker) and aflatoxin B1 (a potent carcinogen), which provided substantially enhanced detection sensitivities compared to conventional enzyme-based assays.