No beneficial effects of aspirin on secondary cardiovascular prevention in patients with type 2 diabetes using non‐steroidal anti‐inflammatory drugs
No beneficial effects of aspirin on secondary cardiovascular prevention in patients with type 2 diabetes using non‐steroidal anti‐inflammatory drugs
复制标题
阿司匹林对使用非甾体类抗炎药的 2 型糖尿病患者的心血管二级预防没有有益作用
DOI：
10.1111/dom.13737
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kajio Hiroshi
中科院分区：
文献类型：
--
作者：
Tsujimoto Tetsuro;Kajio Hiroshi
关于非甾体抗炎药（NSAID）和阿司匹林在2型糖尿病患者的二级心血管预防中是否相互作用的证据很少。这是一项观察性研究，使用来自糖尿病心血管风险控制行动和后续研究的数据。使用考克斯比例风险模型计算死亡率的风险比（HR）和95%置信区间（95% CI），以比较同时使用或不使用NSAID的患者中使用和不使用阿司匹林的至死亡时间。共纳入3600例2型糖尿病合并心血管疾病患者。在平均8.8年的随访期间，948名患者死亡。调整后，未使用NSAID的患者中，使用阿司匹林的患者的全因死亡风险显著低于未使用阿司匹林的患者（HR，0.81; 95% CI，0.70 - 0.93;P= 0.004）。使用NSAID的患者的风险在两组之间没有显著差异。阿司匹林的使用和NSAID的使用之间存在显著的相互作用。在2型糖尿病合并心血管疾病的患者中，使用阿司匹林对使用NSAID的患者没有益处。
There is little evidence on whether non‐steroidal anti‐inflammatory drugs (NSAIDs) and aspirin interact in secondary cardiovascular prevention in type 2 diabetic patients. This is an observational study using data from the Action to Control Cardiovascular Risk in Diabetes and Follow‐on studies. Hazard ratios (HRs) for mortality with 95% confidence intervals (95% CIs) were calculated using Cox proportional hazard models to compare time to death in patients using and not using aspirin who were simultaneously using or not using NSAIDs. A total of 3600 type 2 diabetic patients with cardiovascular disease were included. During a mean follow‐up period of 8.8 years, 948 patients died. After adjustments, the risk of all‐cause mortality in patients not using NSAIDs was significantly lower in those using aspirin than in those not using aspirin (HR, 0.81; 95% CI, 0.70‐0.93;P= 0.004). The risk in patients using NSAIDs did not differ significantly between the two groups. There was a significant interaction between aspirin use and NSAIDs use. In type 2 diabetic patients with cardiovascular disease, aspirin use was not beneficial for those using NSAIDs.
影响因子：
158.5
作者：
Gerstein, Hertzel C.;Miller, Michael E.;Friedewald, William T.
通讯作者：
Friedewald, William T.
使用阿司匹林和布洛芬与单独使用阿司匹林相比发生心肌梗塞的风险。
影响因子：
--
作者：
Taral N. Patel;K. Goldberg
通讯作者：
K. Goldberg
影响因子：
158.5
作者：
Catella-Lawson, F;Reilly, MP;FitzGerald, GA
通讯作者：
FitzGerald, GA