CRANIOSYNOSTOSIS IN RACHITIC SPECTRUM
CRANIOSYNOSTOSIS IN RACHITIC SPECTRUM
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DOI：
10.1016/s0022-3476(64)80192-x
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发表时间：
1964-01-01
影响因子：
5.1
通讯作者：
FRASER, D
中科院分区：
文献类型：
--
作者：
REILLY, BJ;LEEMING, JM;FRASER, D
颅缝过早闭合可能是一种先天性间质缺陷，但也可能继发于代谢性骨病。已知其发生于低磷酸酶症，并且偶尔在维生素D难治性佝偻病中报告。为了确定颅缝早闭在所有形式佝偻病中的真实发病率，对59名9岁以下儿童进行了一项研究，这些儿童当时或以前患有活动性佝偻病。大约三分之一的儿童表现为颅缝早闭，其中3例需要开颅减压。放射学和生化检查结果已试图解释为什么这种代谢型颅缝早闭如此频繁地发生在佝偻病儿童。所有病例的唯一共同特征是在某些时候存在矿化不充分的类骨质。
Premature closure of the cranial sutures can occur as an inherent mesenchymal defect.In addition, however, it can be secondary to metabolic bone disease. It is known to occur in hypophosphatasia and has been occasionally reported in vitamin D—refractory rickets. In order to ascertain the true incidence of craniosynostosis in all forms of rickets, a study was carried out on 59 children under 9 years of age, who were then or had previously been actively rachitic. Approximately one third of the children showed craniosynostosis and of these, 3 required craniectomies for decompression. The radiologic and biochemical findings have been examined in an attempt to explain why this metabolic type of craniosynostosis should occur so frequently in rachitic children. The only feature common to all cases was the presence at some time of inadequately mineralized osteoid.