Myoferlin, a Membrane Protein with Emerging Oncogenic Roles
Myoferlin, a Membrane Protein with Emerging Oncogenic Roles
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DOI：
10.1155/2019/7365913
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Feng Li
中科院分区：
文献类型：
--
作者：
Yimin Dong;Honglei Kang;Huiyong Liu;Jia Wang;Qian Guo;Chao Song;Yunlong Sun;Ya Zhang;Honghua Zhang;Zheng Zhang;Hanfeng Guan;Zhong Fang;Feng Li
Myoferlin (MYOF), initially identified in muscle cells, is a member of the Ferlin family involved in membrane fusion, membrane repair, and membrane trafficking. Dysfunction of this protein is associated with muscular dysfunction. Recently, a growing body of studies have identified MYOF as an oncogenic protein. It is overexpressed in a variety of human cancers and promotes tumorigenesis, tumor cell motility, proliferation, migration, epithelial to mesenchymal transition, angiogenesis as well as metastasis. Clinically, MYOF overexpression is associated with poor outcome in various cancers. It can serve as a prognostic marker of human malignant disease. MYOF drives the progression of cancer in various processes, including surface receptor transportation, endocytosis, exocytosis, intercellular communication, fit mitochondrial structure maintenance and cell metabolism. Depletion of MYOF demonstrates significant antitumor effects both in vitro and in vivo, suggesting that targeting MYOF may produce promising clinical benefits in the treatment of malignant disease. In the present article, we reviewed the physiological function of MYOF as well as its role in cancer, thus providing a general understanding for further exploration of this protein.
