Activation of ventrolateral preoptic neurons during sleep
Activation of ventrolateral preoptic neurons during sleep
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DOI：
10.1126/science.271.5246.216
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发表时间：
1996-01-12
期刊：
影响因子：
56.9
通讯作者：
Saper, CB
中科院分区：
文献类型：
--
作者：
Sherin, JE;Shiromani, PJ;Saper, CB
下丘脑吻端和邻近的基底前脑参与睡眠的产生，但参与这一过程的神经元回路仍然知之甚少。免疫细胞化学被用来鉴定 FOS 蛋白，这是一种立即早期基因产物，存在于一组腹外侧视前神经元中，该神经元在深部被特异性激活。逆行示踪霍乱毒素 B 与 FOS 免疫细胞化学相结合，显示睡眠激活的腹外侧视前神经元支配结节乳头核，下丘脑后部细胞群被认为参与觉醒的调节。下丘脑中的这种单突触通路可能在决定睡眠-觉醒状态中发挥关键作用。
The rostral hypothalamus and adjacent basal forebrain participate in the generation of sleep, but the neuronal circuitry involved in this process remains poorly characterized. Immunocytochemistry was used to identify the FOS protein, an immediate-early gene product, in a group of ventrolateral preoptic neurons that is specifically activated during deep. The retrograde tracer cholera toxin B, in combination with FOS immunocytochemistry, was used to show that sleep-activated ventrolateral preoptic neurons innervate the tuberomammillary nucleus, a posterior hypothalamic cell group thought to participate in the modulation of arousal. This monosynaptic pathway in the hypothalamus may play a key role in determining sleep-wake states.