Function of Nogo-A/Nogo-A Receptor in Alzheimer’s Disease
Function of Nogo-A/Nogo-A Receptor in Alzheimer’s Disease
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Nogo-A/Nogo-A 受体在阿尔茨海默病中的功能
DOI：
10.1111/cns.12387
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发表时间：
2015
影响因子：
5.5
通讯作者：
Meiwan Chen
中科院分区：
文献类型：
--
作者：
Yingqi Xu;Zhongqing Sun;Yitao Wang;Fei Xiao;Meiwan Chen
Nogo-A是一种抑制轴突再生的蛋白质，被认为是哺乳动物损伤后神经再生的主要障碍。近十年来，Nogo-A 在阿尔茨海默病中的新病理生理功能研究取得了快速进展。最近的研究表明，Nogo-A 通过与 Nogo-A 受体结合，在阿尔茨海默病 (AD) 发病机制中发挥重要作用。特别是，Nogo-A/Nogo-A 受体调节淀粉样 b 蛋白 (Ab) 的产生，这被认为是 AD 的主要原因。本文综述了Nogo-A、Nogo-A受体以及AD相关下游信号传导的最新进展以及治疗药物的药理学基础。我们得出结论，Nogo-A/Nogo-A 受体为 AD 的潜在机制和有希望的治疗策略提供了新的见解。
Nogo-A is a protein inhibiting axonal regeneration, which is considered a major obstacle to nerve regeneration after injury in mammals. Rapid progress has been achieved in new physiopathological function of Nogo-A in Alzheimer’s disease in the past decade. Recent research shows that through binding to Nogo-A receptor, Nogo-A plays an important role in Alzheimer’s disease (AD) pathogenesis. Particularly, Nogo-A/Nogo-A receptors modulate the generation of amyloid b-protein (Ab), which is thought to be a major cause of AD. This review describes the recent development of Nogo-A, Nogo-A receptor, and downstream signaling involved in AD and pharmacological basis of therapeutic drugs. We concluded the Nogo-A/Nogo-A receptor provide new insight into potential mechanisms and promising.therapy strategies in AD.