Tunneling nanotubes, an emerging intercellular communication route in development
Tunneling nanotubes, an emerging intercellular communication route in development
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DOI：
10.1016/j.mod.2012.11.006
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发表时间：
2013-06-01
影响因子：
2.6
通讯作者：
Wang, Xiang
中科院分区：
文献类型：
--
作者：
Gerdes, Hans-Hermann;Rustom, Amin;Wang, Xiang
多细胞生物体的发展涉及到一个全面的、严格管制的细胞间通讯系统，以协调单个细胞的活动和行为。从受体介导的信号转导到通过缝隙连接的接触依赖通信，不同的信号通路实现了这些复杂的相互作用。在这篇综述中，我们将重点介绍一种新型的细胞间连接-隧道纳米管(TNT)，它已经在体外许多细胞类型中观察到，最近也在体内不同物种的胚胎发育中观察到。我们将总结它们在细胞间信号传递中的功能作用的最新见解，特别关注发育中的胚胎细胞之间依赖TNT的电耦合。最后，将讨论这些新发现在发育过程中的潜在影响，特别是在细胞迁移方面。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
The development of multi-cellular organisms involves a comprehensive and tightly regulated cell-to-cell communication system to coordinate the activity and behavior of individual cells. Diverse signaling pathways ranging from receptor-mediated signal transduction to contact-dependent communication via gap junctions achieve these complex interactions. In this review, we will focus on a new type of intercellular connection, the tunneling nanotube (TNT), which has been observed in many cell types in vitro and recently also in developing embryos of different species in vivo. We will summarize the latest insights into their functional roles in cell-to-cell signaling with a particular focus on the TNT-dependent electrical coupling between developing embryonic cells. Finally, potential implications of these new findings in the light of developmental processes, particularly in cell migration, will be discussed. (C) 2012 Elsevier Ireland Ltd. All rights reserved.