Cancer stem cell radioresistance and enrichment: where frontline radiation therapy may fail in lung and esophageal cancers.
Cancer stem cell radioresistance and enrichment: where frontline radiation therapy may fail in lung and esophageal cancers.
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DOI：
10.3390/cancers3011232
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发表时间：
2011-03
期刊：
影响因子：
5.2
通讯作者：
Chang JY
中科院分区：
文献类型：
--
作者：
Nguyen GH;Murph MM;Chang JY
许多研究强调了癌症干细胞(CSC)在包括肺癌和食道癌在内的各种癌症的发生和发展中所起的作用。最近，有人提出CSCs的存在会影响治疗效果和患者预后。在回顾这一新的癌症生物学领域时，我们将概述目前关于肺和食道肿瘤干细胞以及肿瘤干细胞的辐射抵抗的文献，并讨论这些发现的潜在治疗应用。
Many studies have highlighted the role cancer stem cells (CSC) play in the development and progression of various types of cancer including lung and esophageal cancer. More recently, it has been proposed that the presence of CSCs affects treatment efficacy and patient prognosis. In reviewing this new area of cancer biology, we will give an overview of the current literature regarding lung and esophageal CSCs and radioresistance of CSC, and discuss the potential therapeutic applications of these findings.