Animal Models of Aging Research: Implications for Human Aging and Age-Related Diseases
Animal Models of Aging Research: Implications for Human Aging and Age-Related Diseases
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DOI：
10.1146/annurev-animal-022114-110829
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
de Cabo, Rafael
中科院分区：
文献类型：
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作者：
Mitchell, Sarah J.;Scheibye-Knudsen, Morten;de Cabo, Rafael
衰老的特征是发病率增加和功能下降，最终导致生物体死亡。衰老是许多人类疾病的最大风险因素，了解衰老过程可能有助于开发与年龄相关疾病的新治疗方法。人类在衰老研究中的使用受到许多因素的影响，包括伦理问题;环境和社会因素;也许最重要的是，他们的自然寿命很长。虽然人类疾病的细胞模型提供了有价值的机制信息，但它们的局限性在于它们可能无法复制体内生物学。几乎所有的生物都会衰老，因此动物模型对于研究衰老是有用的。在此，我们回顾了目前用于衰老研究的一些主要模型，并讨论了它们的好处和陷阱，包括已知的延长寿命和健康寿命的干预措施。最后，我们讨论了动物模型在衰老研究中的未来。
Aging is characterized by an increasing morbidity and functional decline that eventually results in the death of an organism. Aging is the largest risk factor for numerous human diseases, and understanding the aging process may thereby facilitate the development of new treatments for age-associated diseases. The use of humans in aging research is complicated by many factors, including ethical issues; environmental and social factors; and perhaps most importantly, their long natural life span. Although cellular models of human disease provide valuable mechanistic information, they are limited in that they may not replicate the in vivo biology. Almost all organisms age, and thus animal models can be useful for studying aging. Herein, we review some of the major models currently used in aging research and discuss their benefits and pitfalls, including interventions known to extend life span and health span. Finally, we conclude by discussing the future of animal models in aging research.