Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials
Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials
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DOI：
10.1136/bmj.38950.561400.55
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发表时间：
2006-10-14
影响因子：
105.7
通讯作者：
Jones, Graeme
中科院分区：
文献类型：
--
作者：
Winzenberg, Tania;Shaw, Kelly;Jones, Graeme
ObjectiveTo assess effectiveness of calcium supplementation for improving bone mineral density in healthy children and to determine if any effect is modified by other factors and stabilizes after supplementation stops.Design Meta-analysis.Data sources电子书目数据库，手工检索会议论文集，并联系作者获取未发表的数据。在健康儿童中进行的钙补充剂随机安慰剂对照试验，持续至少三个月，并在至少六个月的随访后测量骨骼结果。两名评审员独立提取数据并评估质量。荟萃分析主要使用固定效应模型与结果作为标准化的平均differentiation.Results，我们包括19项研究，涉及2859名儿童。补钙对股骨颈或腰椎的骨密度没有影响。脊椎对全身骨矿物质含量（标准化平均差异为0.14，95%置信区间为0.01至0.27）和上肢骨矿物质密度（0.14，0.04至0.24）的影响较小。这种效应在补充结束后仅在上肢持续存在（0.14，0.01至0.28）。没有证据表明，性别，基线钙摄入量，青春期阶段，种族，或体力活动水平修改的effect.Conclusions在上肢的骨密度的钙补充的小影响是不太可能降低骨折的风险，无论是在童年或以后的生活，在一定程度上的重大公共卫生的重要性。
Objectives To assess the effectiveness of calcium supplementation for improving bone mineral density in healthy children and to determine if any effect is modified by other factors and persists after supplementation stops.Design Meta-analysis.Data sources Electronic bibliographic databases, hand searching of conference proceedings, and contacting authors for unpublished data.Review methods We included. randomised placebo controlled trials of calcium supplementation in healthy children that lasted at least three months and had bone outcomes measured after at least six months of follow-up. Two reviewers independently extracted data and assessed quality. Meta-analyses predominantly used fixed effects models with outcomes given as standardised mean differences.Results We included 19 studies involving 2859 children. Calcium supplementation had no effect on bone mineral density at the femoral neck or lumbar. spine. There was a small effect on total body bone mineral content (standardised mean difference 0.14, 95% confidence interval 0.01 to 0.27) and upper limb bone mineral density (0.14, 0.04 to 0.24). This effect persisted after the end of supplementation only at the upper limb (0.14, 0.01 to 0.28). There was no evidence that sex, baseline calcium intake, pubertal stage, ethnicity, or level of physical activity modified the effect.Conclusions The small effect of calcium supplementation on bone mineral density in the upper limb is unlikely to reduce the risk of fracture, either in childhood or later life, to a degree of major public health importance.