Apolipoprotein E and Alzheimer's disease: Strength of association is related to age at onset
Apolipoprotein E and Alzheimer's disease: Strength of association is related to age at onset
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DOI：
10.1159/000106888
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发表时间：
1996-09-01
期刊：
影响因子：
--
通讯作者：
Fink, JK
中科院分区：
文献类型：
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作者：
Murman, DL;Foster, NL;Fink, JK
与对照组相比，阿尔茨海默病（AD）患者的载脂蛋白E（apoE）等位基因频率增加，并受到其他遗传因素和症状发作时年龄的影响。我们通过比较正常老年对照组（n = 107）和AD患者（n = 123）的apoE ε 4等位基因频率，研究了AD症状发作时的年龄与apoE之间的关系。此外，还测定了有和无apoE β 4等位基因的AD患者的症状发作年龄分布。我们观察到在AD发病年龄55 - 75岁之间apoE β 4等位基因频率增加，但在发病年龄的极端（即45 - 54岁和75岁以后发病）没有增加。我们的数据表明，具有apoE β 4等位基因增加了AD患者在发病年龄的中间范围内出现症状的可能性。在AD发病年龄的极端，非apoE因素，包括其他遗传因素和年龄，是发展AD的风险更重要的决定因素。
Apolipoprotein E (apoE) epsilon 4 allele frequency among Alzheimer's disease (AD) patients is increased compared to control subjects and is influenced by the presence of other genetic factors and age at symptom onset. We examined the relationship between age at AD symptom onset and apoE by comparing the apoE epsilon 4 allele frequency of normal, elderly control subjects (n = 107) to that in AD patients (n = 123), divided into four age-at-onset periods. Additionally, the distribution of symptom onset ages of AD patients with and without apoE epsilon 4 alleles was determined. We observed increased apoE epsilon 4 allele frequencies between the AD onset ages of 55 and 75 years, but not at the extremes of onset ages (i.e. onset between 45 and 54 years of age and after age 75). Our data suggests that having an apoE epsilon 4 allele increases the likelihood that AD patients will develop symptoms in the middle range of onset ages. At the extremes of AD onset ages, non-apoE factors, including other genetic factors and age, are more important determinants of risk of developing AD.