Molecular Epidemiology of Newcastle Disease in Mexico and the Potential Spillover of Viruses from Poultry into Wild Bird Species
Molecular Epidemiology of Newcastle Disease in Mexico and the Potential Spillover of Viruses from Poultry into Wild Bird Species
复制标题
DOI：
10.1128/aem.00993-13
复制
发表时间：
2013-08-01
影响因子：
4.4
通讯作者：
Afonso, Claudio L.
中科院分区：
文献类型：
--
作者：
Garcia, Stivalis Cardenas;Lopez, Roberto Navarro;Afonso, Claudio L.
新城疫是影响世界养禽业的最重要的健康问题之一，由新城疫强毒株引起。新城疫病毒被认为是美洲几个国家的地方病，包括墨西哥。为了控制新城疫的爆发和传播，已经建立了密集的疫苗接种计划，其中包括用至少60年前分离的菌株配制的疫苗。这些疫苗与2008年之前一直在墨西哥传播的新城疫强毒在基因上不同。为了研究新城疫病毒在墨西哥的最新流行情况，对2008-2011年间从墨西哥不同地区的自由生活野鸟、圈养野鸟和家禽中分离到的28株新城疫病毒进行了系统发育和生物学特征的研究。在这里，我们证明，直到最近，来自V型的强毒病毒仍在该国继续传播和进化。所有新城疫低毒力毒株均与LaSota(基因II)和PHY-LMV42(基因I)疫苗株高度相似，主要从未免疫的自由生活的野鸟和圈养的野鸟中分离出来。这些发现，加上在墨西哥动物园发现的两种毒力强的病毒，表明新城疫病毒可能正在从家禽逃逸到环境中。
Newcastle disease, one of the most important health problems that affects the poultry industry around the world, is caused by virulent strains of Newcastle disease virus. Newcastle disease virus is considered to be endemic in several countries in the Americas, including Mexico. In order to control Newcastle disease outbreaks and spread, intensive vaccination programs, which include vaccines formulated with strains isolated at least 60 years ago, have been established. These vaccines are dissimilar in genotype to the virulent Newcastle disease viruses that had been circulating in Mexico until 2008. Here, 28 isolates obtained between 2008 and 2011 from different regions of Mexico from free-living wild birds, captive wild birds, and poultry were phylogenetically and biologically characterized in order to study the recent epidemiology of Newcastle disease viruses in Mexico. Here we demonstrate that, until recently, virulent viruses from genotype V continued to circulate and evolve in the country. All of the Newcastle disease viruses of low virulence, mostly isolated from nonvaccinated free-living wild birds and captive wild birds, were highly similar to LaSota (genotype II) and PHY-LMV42 (genotype I) vaccine strains. These findings, together with the discovery of two virulent viruses at the Mexican zoo, suggest that Newcastle disease viruses may be escaping from poultry into the environment.