THE USE OF CAPILLARY ELECTROPHORESIS FOR THE DETERMINATION OF HEMOGLOBIN-VARIANTS

THE USE OF CAPILLARY ELECTROPHORESIS FOR THE DETERMINATION OF HEMOGLOBIN-VARIANTS
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DOI:
10.1002/elps.11501601247
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发表时间:
1995-08-01
期刊:
影响因子:
2.9
通讯作者:
GIARDINA, B
GIARDINA, B
中科院分区:
生物学3区
文献类型:
--
作者:
CASTAGNOLA, M;MESSANA, I;GIARDINA, B

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The application of capillary electrophoresis and related techniques for the detection of hemoglobin variants is described. Capillary zone electrophoresis (CZE) was applied for the analysis of intact tetrameric hemoglobin. CZE under denaturing conditions was used for the separation of globin chains. Both CZE and micellar electrokinetic capillary chromatography were applied for a fast and sensitive separation of tryptic digests and for the analysis of amino acid derivatives.