Ultrasound-guided percutaneous implantation of rabbit VX2 carcinoma, using a coaxial technique and gelfoam pellet injection combination to establish a rabbit liver tumor model
Ultrasound-guided percutaneous implantation of rabbit VX2 carcinoma, using a coaxial technique and gelfoam pellet injection combination to establish a rabbit liver tumor model
复制标题
超声引导下经皮植入兔VX2癌，采用同轴技术与明胶海绵注射相结合建立兔肝脏肿瘤模型
DOI：
10.5152/dir.2021.20533
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发表时间：
2022-01-01
影响因子：
2.1
通讯作者：
Zhou, Shi
中科院分区：
文献类型：
--
作者：
Cheng, Zhimei;Zhang, Shuai;Zhou, Shi
目的探讨同轴植入联合明胶海绵颗粒注射建立兔VX2肝肿瘤模型的安全性和种植率。方法60只雄性新西兰大白兔，随机分为3组，每组20只，A组单纯单针植入，B组单针注射明胶海绵颗粒，C组同轴注射明胶海绵颗粒。比较两组移植后2周的肝成瘤率和移植瘤至肝外的比例。结果60只兔均建立了VX2肝肿瘤模型(100%，60/60)。异位种植率A组为70%(14/20)，B组为35%(7/20)，C组为5%(1/20)，组间差异有统计学意义(P
PURPOSEWe aimed to investigate the safety and tumor seeding rate of a coaxial implantation technique combined with injection of a gelfoam pellet in establishing a VX2 liver tumor model in rabbits.METHODSA VX2 liver tumor model was established in 60 male New Zealand white rabbits, which were randomly divided into 3 groups (20 in each group) based on implantation technique (all performed under ultrasound guidance): group A, single needle only; group B, single needle with injection of a gelfoam pellet; or group C, coaxial technique with injection of a gelfoam pellet. The rates of liver tumor formation and tumor seeding to extrahepatic tissues were compared 2 weeks after implantation. Data were also collected regarding procedure time, number of punctures, occurrence of complications, and mortality rate.RESULTSA VX2 liver tumor model was established in all 60 rabbits (100%, 60/60). Ectopic implantation rate was 70% (14/20) in group A, 35% (7/20) in group B, and 5% (1/20) in group C, with significant difference among the groups (P