Prognostic factors and optimal treatment strategy for intrahepatic nodular recurrence after curative resection of hepatocellular carcinoma
Prognostic factors and optimal treatment strategy for intrahepatic nodular recurrence after curative resection of hepatocellular carcinoma
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DOI：
10.1245/s10434-007-9671-6
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发表时间：
2008-02-01
影响因子：
3.7
通讯作者：
Kim, Byong-Ro
中科院分区：
文献类型：
--
作者：
Choi, Gi-Hong;Kim, Dong-Hyun;Kim, Byong-Ro
背景：肝内复发是肝细胞癌根治性切除术后的主要问题。然而，肝内复发患者的最有效治疗方法仍不清楚。此外，各种治疗方式的选择，如重复切除，局部消融治疗，经动脉化疗栓塞术是只适用于肝内结节复发的患者。方法：353例接受根治性切除，97例肝内结节复发的患者进行了回顾性研究。分析复发后生存的预后因素和治疗方式。患者被分为两组，对照组和进展组，根据他们的反应，以初步治疗复发tumors.Results：1，3，5年总生存率与肝内结节复发患者复发后分别为91.0%，71.0%，37.5%，分别。多因素分析显示，早期复发（
Background: Intrahepatic recurrence is a major problem after curative resection of hepatocellular carcinoma. However, the most effective treatments for patients with intrahepatic recurrence still remain unclear. In addition, the selection of various treatment modalities such as repeat resection, local ablation therapy, and transarterial chemoembolization is only applicable to patients with intrahepatic nodular recurrence.Methods: Of 353 patients who underwent curative resection, 97 patients with intrahepatic nodular recurrence were retrospectively studied. The prognostic factors for survival after recurrence and treatment modalities were analyzed. The patients were divided into two groups, a control group and a progression group, according to their response to initial treatment for recurrent tumors.Results: The 1-, 3-, and 5-year overall survival rates after recurrence in patients with intrahepatic nodular recurrence were 91.0%, 71.0%, and 37.5%, respectively. Multivariate analysis revealed that early recurrence (