Worldwide analysis of multiple microsatellites: Language diversity has a detectable influence on DNA diversity
Worldwide analysis of multiple microsatellites: Language diversity has a detectable influence on DNA diversity
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DOI：
10.1002/ajpa.20622
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发表时间：
2007-08-01
影响因子：
2.8
通讯作者：
Barbujani, Guido
中科院分区：
文献类型：
--
作者：
Belle, Elise M. S.;Barbujani, Guido
先前关于人类群体所讲的语言与这些群体成员所携带的基因之间的相关性的研究，由于可用的遗传标记数量少，以及在处理语言数据时的近似值，受到了限制。在这项研究中，我们分析了分布在所有常染色体上的大量多态微卫星位点（377个），并使用Ruhlen的语言分类来研究地理和语言在塑造全球范围内人类DNA多样性分布中的相对作用。为此，我们进行了三种不同的分析：(i)我们通过分子方差分析（AMOVA）将遗传方差根据语言群体划分为三个层次的群体细分水平；（ii）我们通过一系列Mantel的测试量化了遗传和语言差异测量之间的相关性；（三）我们测试了语言差异是否会在种群间基因变化增加的已知区域内增加。基因差异似乎更能反映地理差异而非语言差异。然而，我们的分析表明，语言差异在基因组水平上对DNA多样性也有可检测的影响，超过地理距离的影响。
Previous studies of the correlations between the languages spoken by human populations and the genes carried by the members of those populations have been limited by the small amount of genetic markers available and by approximations in the treatment of linguistic data. In this study we analyzed a large collection of polymorphic microsatellite loci (377), distributed on all autosomes, and used Ruhlen's linguistic classification, to investigate the relative roles of geography and language in shaping the distribution of human DNA diversity at a worldwide scale. For this purpose, we performed three different kinds of analysis: (i) we partitioned genetic variances at three hierarchical levels of population subdivision according to language group by means of a molecular analysis of variance (AMOVA); (ii) we quantified by a series of Mantel's tests the correlation between measures of genetic and linguistic differentiation; and (iii) we tested whether linguistic differences are increased across known zones of increased genetic change between populations. Genetic differences appear to more closely reflect geographic than linguistic differentiation. However, our analyses show that language differences also have a detectable effect on DNA diversity at the genomic level, above and beyond the effects of geographic distance.