[Depression and perimenopause: a review].
[Depression and perimenopause: a review].
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DOI：
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发表时间：
2009-07
影响因子：
1.5
通讯作者：
M. García-Portilla
中科院分区：
文献类型：
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作者：
M. García-Portilla
抑郁症状和疾病在一生中非常普遍，尤其是在中年人中。从青春期开始，女性患不同抑郁症的风险比男性高 1.5-3 倍。传统上，人们认为过渡到更年期或围绝经期是抑郁症易感性较高的时期，尽管存在一定程度的争议。这一时期似乎与抑郁症状和新发抑郁症的出现有关，特别是在存在抑郁背景的情况下。关于其病因，有人提出了遗传、激素、心理和社会文化因素，但没有可靠的数据支持任何这些解释。治疗基本上取决于疾病的严重程度，包括抗抑郁药和/或心理治疗。激素替代疗法（雌激素）的维持治疗正在讨论中。
Depressive symptoms and disorders are highly prevalent throughout life, particularly in the middle-aged. From adolescence, women have a 1.5-3 times higher risk than men of suffering different depressive disorders. Traditionally, it has been assumed that transition to menopause, or perimenopause, is a period of higher depressive vulnerability, although there is some degree of controversy. This period seems to be associated with the appearance of both depressive symptoms and de novo depressive disorders, particularly if a background of depression exists. With regard to its etiopathogeny, genetic, hormonal, psychological and sociocultural factors have been suggested, but there are no solid data that support any of these explanations. Treatment basically depends on the severity of the disorder and includes antidepressants and/or psychotherapy. Maintained treatment with hormone replacement therapy (estrogens) is under discussion.