Serial regulation of transcriptional regulators in the yeast cell cycle
Serial regulation of transcriptional regulators in the yeast cell cycle
复制标题
DOI：
10.1016/s0092-8674(01)00494-9
复制
发表时间：
2001-09-21
期刊：
影响因子：
64.5
通讯作者：
Young, RA
中科院分区：
文献类型：
--
作者：
Simon, I;Barnett, J;Young, RA
全基因组定位分析用于确定酵母细胞周期基因表达程序是如何被九种已知的细胞周期转录激活因子中的每一种调控的。我们发现，在细胞周期的一个阶段发挥作用的细胞周期转录激活因子调节在下一个阶段发挥作用的转录激活因子。转录激活因子的这种串联调节形成了一个相互连接的调节网络，这个网络本身就是一个循环。我们的研究结果还揭示了9个转录调节因子如何协调调节全局基因表达和不同阶段特异性功能，以产生连续的细胞事件循环。这些信息构成了控制细胞周期的转录调控网络的完整图谱的基础。
Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators. We found that cell cycle transcriptional activators that function during one stage of the cell cycle regulate transcriptional activators that function during the next stage. This serial regulation of transcriptional activators forms a connected regulatory network that is itself a cycle. Our results also reveal how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events. This information forms the foundation for a complete map of the transcriptional regulatory network that controls the cell cycle.