The gut microbiota is a transmissible determinant of skeletal maturation.
The gut microbiota is a transmissible determinant of skeletal maturation.
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DOI：
10.7554/elife.64237
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发表时间：
2021-01-12
期刊：
影响因子：
7.7
通讯作者：
Pacifici R
中科院分区：
文献类型：
--
作者：
Tyagi AM;Darby TM;Hsu E;Yu M;Pal S;Dar H;Li JY;Adams J;Jones RM;Pacifici R
遗传因素是人类骨量变化的主要原因，但非遗传因素的影响在很大程度上仍不清楚。通过母子传播、同居或粪便材料移植(FMT)研究，我们调查了肠道微生物群对骨骼成熟的影响。我们证明，肠道微生物群是小鼠骨骼结构和周转的可传播调节因子。此外，我们发现，获得一种特定的细菌菌株，分段丝状细菌(SFB)，一种诱导肠道Th17细胞扩张的肠道微生物，足以对骨骼成熟产生负面影响。这些发现具有重大的翻译意义，因为微生物组转移的方法或时机的确定可能会导致细菌治疗干预措施的发展，以优化人类的骨骼成熟。此外，在治疗性FMT过程中，转移能够触发人类Th17细胞扩张的SFB样微生物可能会导致粪便材料接受者的显著骨丢失。
Genetic factors account for the majority of the variance of human bone mass, but the contribution of non-genetic factors remains largely unknown. By utilizing maternal/offspring transmission, cohabitation, or fecal material transplantation (FMT) studies, we investigated the influence of the gut microbiome on skeletal maturation. We show that the gut microbiome is a communicable regulator of bone structure and turnover in mice. In addition, we found that the acquisition of a specific bacterial strain, segmented filamentous bacteria (SFB), a gut microbe that induces intestinal Th17 cell expansion, was sufficient to negatively impact skeletal maturation. These findings have significant translational implications, as the identification of methods or timing of microbiome transfer may lead to the development of bacteriotherapeutic interventions to optimize skeletal maturation in humans. Moreover, the transfer of SFB-like microbes capable of triggering the expansion of human Th17 cells during therapeutic FMT procedures could lead to significant bone loss in fecal material recipients.