Myocardial viability of the peri-infarct region measured by T1 mapping post manganese-enhanced MRI correlates with LV dysfunction.
Myocardial viability of the peri-infarct region measured by T1 mapping post manganese-enhanced MRI correlates with LV dysfunction.
复制标题
通过锰增强 MRI 后 T1 映射测量的梗死周围区域的心肌活力与左心室功能障碍相关。
DOI：
10.1016/j.ijcard.2019.01.101
复制
发表时间：
2019
影响因子：
3.5
通讯作者：
Yang,PhillipC
中科院分区：
文献类型：
--
作者：
Tada,Yuko;Heidary,Shahriar;Tachibana,Atsushi;Zaman,Junaid;Neofytou,Evgenios;Dash,Rajesh;Wu,JosephC;Yang,PhillipC
背景锰增强磁共振成像（MEMRI）是基于细胞内锰通过L-型钙通道的摄取来检测存活心肌细胞的。本研究的目的是量化心肌存活率的基础上，在梗死核心（IC），梗死周围区域（PIR）和远程心肌（RM）使用T1映射之前和之后MEMRI和评估其与心脏功能和mammogenesis.MethodsFifteen雌性猪有一个60分钟的球囊缺血再灌注损伤的LAD。4周后进行MRI（Signa 3 T，GE Healthcare）和电生理研究（EPS）。在左心室短轴上采集MEMRI和延迟钆增强MRI（DEMRI）。DEMRI阳性的总梗死面积被细分为MEMRI阴性的非活性IC和MEMRI阳性的活性PIR区域。进行T1定位以评估每个区域的原生T1、MEMRI后T1和Δ R1（R1 post-R1 pre，其中R1等于1/T1）。结果PIR的特征为中间自然T1（1530.5 ± 75.2 ms），而IC（1634.7 ± 88.4 ms，p= 0.001）和RM（1406.4 ± 37.9 ms，p< 0.0001）。PIR的MEMRI后T1（1136.3 ± 99.6 ms）低于IC（1262.6 ± 126.8 ms，p= 0.005），PIR的Δ R1（0.23 ± 0.08 s-1）高于IC（0.18 ± 0.09 s-1，p= 0.04），表明PIR的心肌锰摄取高于IC。PIR的Post-MEMRI T1（r=-0.57，p = 0.02）和delta R1（r= 0.51，p = 0.04）与LVEF显著相关。在IR后的亚急性期，通过后MEMRI T1测量的PIR活力与心脏功能相关。
BackgroundManganese-enhanced MRI (MEMRI) detects viable cardiomyocytes based on the intracellular manganese uptake via L-type calcium-channels. This study aimed to quantify myocardial viability based on manganese uptake by viable myocardium in the infarct core (IC), peri-infarct region (PIR) and remote myocardium (RM) using T1 mapping before and after MEMRI and assess their association with cardiac function and arrhythmogenesis.MethodsFifteen female swine had a 60-minute balloon ischemia-reperfusion injury in the LAD. MRI (Signa 3T, GE Healthcare) and electrophysiological study (EPS) were performed 4 weeks later. MEMRI and delayed gadolinium-enhanced MRI (DEMRI) were acquired on LV short axis. The DEMRI positive total infarct area was subdivided into the regions of MEMRI-negative non-viable IC and MEMRI-positive viable PIR. T1 mapping was performed to evaluate native T1, post-MEMRI T1, and delta R1 (R1post-R1pre, where R1 equals 1/T1) of each territory. Their correlation with LV function and EPS data was assessed.ResultsPIR was characterized by intermediate native T1 (1530.5 ± 75.2 ms) compared to IC (1634.7 ± 88.4 ms,p= 0.001) and RM (1406.4 ± 37.9 ms,p< 0.0001). Lower post-MEMRI T1 of PIR (1136.3 ± 99.6 ms) than IC (1262.6 ± 126.8 ms,p= 0.005) and higher delta R1 (0.23 ± 0.08 s−1) of PIR than IC (0.18 ± 0.09 s−1,p= 0.04) indicated higher myocardial manganese uptake of PIR compared to IC. Post-MEMRI T1 (r= −0.57,p= 0.02) and delta R1 (r= 0.51,p= 0.04) of PIR correlated significantly with LVEF.ConclusionsPIR is characterized by higher manganese uptake compared to the infarct core. In the subacute phase post-IR, PIR viability measured by post-MEMRI T1 correlates with cardiac function.