Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala
Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala
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DOI：
10.1038/nn1871
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发表时间：
2007-04-01
影响因子：
25
通讯作者：
LeDoux, Joseph E.
中科院分区：
文献类型：
--
作者：
Doyere, Valerie;Debiec, Jacek;LeDoux, Joseph E.
当记忆被重新激活时，它会进入一种不稳定的、依赖于蛋白质合成的状态，这个过程被称为再巩固。在这里，我们表明，在大鼠的恐惧记忆提取产生的突触增强的外侧杏仁核，是选择性的重新激活的记忆，和重新巩固的中断与减少突触增强的外侧杏仁核。因此，提取和再巩固都通过选择性靶向突触的突触可塑性来改变记忆。
When reactivated, memories enter a labile, protein synthesis dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses.