Independence of VNTR alleles defined as fixed bins.
Independence of VNTR alleles defined as fixed bins.
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作者：
B. S. Weir
本文分析了联邦调查局在美国人群中6个非连锁可变数目串联重复序列（VNTR）位点收集的数据。数据库已经建立了来自佛罗里达、得克萨斯和加州的高加索人、黑人和西班牙裔人的VNTR谱。很少有证据表明VNTR片段对的长度之间的相关性，在基因座内或之间。当片段长度合并成离散箱，也有一些证据表明，在所有基因型不平衡，基因座内或之间，高加索人的数据库，虽然一些不平衡被发现的黑人和西班牙裔数据库。当测试仅限于杂合子个体时，未发现高加索人或黑人数据库的不平衡。在全局不平衡的情况下，局部检验可以应用于特定的基因型。结果表明，在bin水平，频率的VNTR配置文件通常可以估计为产品的组成元素的频率。这克服了在数据库中不存在任何特定概况时估计人口频率的问题。有一些证据表明，在每个高加索人，黑人和西班牙裔数据库内的地理样本之间，在单个bin水平上存在不同的频率，并且有相当多的证据表明三个数据库之间存在差异。这些差异是不太明显的四个位点的配置文件的频率。
An analysis is presented of data collected by the Federal Bureau of Investigation at six unlinked variable number of tandem repeats (VNTR) loci for the United States population. Databases have been constructed of VNTR profiles of Caucasians, Blacks and Hispanics from Florida, Texas and California. There was very little evidence for correlations between lengths for pairs of VNTR fragments, within or between loci. When the fragment lengths were amalgamated into discrete bins, there was also little evidence for disequilibrium over all genotypes, within or between loci, for the Caucasian database, although some disequilibrium was found for the Black and Hispanic databases. No disequilibrium was found for the Caucasian or Black databases when tests were confined to heterozygous individuals. In cases of global disequilibrium, local tests can be applied to specific genotypes. The results suggest that, at the bin level, frequencies of VNTR profiles can generally be estimated as the products of the frequencies of the constituent elements. This overcomes the problem of estimating population frequencies when any particular profile does not exist in the database. There is some evidence for different frequencies, at the individual bin level, between geographic samples within each of the Caucasian, Black and Hispanic databases, and considerable evidence for differences between the three databases. These differences are less evident for the frequencies of four-locus profiles.