Acute Ischemic Stroke and COVID-19 An Analysis of 27 676 Patients
Acute Ischemic Stroke and COVID-19 An Analysis of 27 676 Patients
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DOI：
10.1161/strokeaha.120.031786
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发表时间：
2021-03-01
期刊：
影响因子：
8.3
通讯作者：
Shyu, Chi-Ren
中科院分区：
文献类型：
--
作者：
Qureshi, Adnan, I;Baskett, William, I;Shyu, Chi-Ren
背景和目的：急性缺血性卒中可能发生在2019冠状病毒病（COVID-19）患者中，但风险因素、院内事件和结局尚未在大型队列中得到充分研究。我们确定了COVID-19伴或不伴急性缺血性卒中患者的风险因素、合并症和结局，并与未伴COVID-19和急性缺血性卒中的患者进行了比较。方法：我们使用Cerner去识别COVID-19数据集分析了54家医疗机构的数据。数据集包括急诊科或住院患者，其出院诊断代码可能与疑似或暴露于COVID-19或确诊的COVID-19相关。结果：在8163例COVID-19患者中，共有103例（1.3%）患者发生急性缺血性卒中。在所有COVID-19患者中，急性缺血性卒中患者中高血压、糖尿病、高脂血症、房颤和充血性心力衰竭患者的比例明显较高。急性缺血性卒中与出院至目的地而非家中或死亡相关（相对危险度，2.1 [95%CI，1.6-2.4]; P
Background and Purpose:Acute ischemic stroke may occur in patients with coronavirus disease 2019 (COVID-19), but risk factors, in-hospital events, and outcomes are not well studied in large cohorts. We identified risk factors, comorbidities, and outcomes in patients with COVID-19 with or without acute ischemic stroke and compared with patients without COVID-19 and acute ischemic stroke.Methods:We analyzed the data from 54 health care facilities using the Cerner deidentified COVID-19 dataset. The dataset included patients with an emergency department or inpatient encounter with discharge diagnoses codes that could be associated to suspicion of or exposure to COVID-19 or confirmed COVID-19.Results:A total of 103 (1.3%) patients developed acute ischemic stroke among 8163 patients with COVID-19. Among all patients with COVID-19, the proportion of patients with hypertension, diabetes, hyperlipidemia, atrial fibrillation, and congestive heart failure was significantly higher among those with acute ischemic stroke. Acute ischemic stroke was associated with discharge to destination other than home or death (relative risk, 2.1 [95% CI, 1.6-2.4]; P