Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress
Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress
复制标题
五味子乙素通过抑制过度炎症和氧化应激来缓解糖尿病肾病
DOI：
10.1016/j.bbrc.2018.11.128
复制
发表时间：
2019-01-01
影响因子：
3.1
通讯作者：
Liang, Guang
中科院分区：
文献类型：
--
作者：
Mou, Zhenxin;Feng, Zhiguo;Liang, Guang
糖尿病肾病（diabetic nephropathy，DN）是糖尿病患者肾小球毛细血管损伤所致的一种进行性肾脏疾病，炎症和氧化应激是其重要的致病因素。迫切需要开发有效的治疗药物。天然药物是活性先导化合物的丰富资源。它们将为DN的治疗提供新的机会。本研究旨在探讨五味子醇甲B（SchB）对糖尿病肾病的保护作用及其机制。在糖尿病小鼠模型中口服SchB可显著减轻高血糖诱导的肾损伤，并伴有尿肌酐和白蛋白水平维持在与对照非糖尿病小鼠相似的水平。肾组织病理学检查显示SchB能显著抑制肾纤维化的发生和肾细胞凋亡。SchB对DN的保护作用与抑制炎症反应和氧化应激有关。这些结果表明SchB可能是一种潜在的治疗DN的药物。此外，我们的研究结果提供了一个更全面的了解NF-κ B B和Nrf 2在DN中的调节作用，表明他们可能是重要的治疗靶点。(C)2018爱思唯尔公司All rights reserved.
Diabetic nephropathy (DN) is a progressive kidney disease due to glomerular capillary damage in diabetic patients, with inflammation and oxidative stress implicated as crucial pathogenic factors. There is an urgent need to develop effective therapeutic drug. Natural medicines are rich resources for active lead compounds. They would provide new opportunities for the treatment of DN. The present study was designed to investigate the protective effects of Schisandrin B (SchB) on DN and to delineate the underlying mechanism. Oral administration of SchB in the diabetic mouse model significantly alleviated hyperglycemia-induced renal injury, which was accompanied by maintenance of urine creatinine and albumin levels at similar to those of control non-diabetic mice. Histological examination of renal tissue indicated that both development of fibrosis and renal cell apoptosis were dramatically inhibited by SchB. The protective effect of SchB on DN associated with suppression of inflammatory response and oxidative stress. These results strongly suggested that SchB could be a potential therapeutic agent for treatment of DN. Moreover, our findings provided a fuller understanding of the regulatory role of NF-kappa B and Nrf2 in DN, indicating that they could be important therapeutic targets. (C) 2018 Elsevier Inc. All rights reserved.