PHARMACOKINETICS AND TOXICITY OF INTRAARTERIAL ADRIAMYCIN FOR HEPATOCELLULAR-CARCINOMA - EFFECT OF COADMINISTRATION OF LIPIODOL
PHARMACOKINETICS AND TOXICITY OF INTRAARTERIAL ADRIAMYCIN FOR HEPATOCELLULAR-CARCINOMA - EFFECT OF COADMINISTRATION OF LIPIODOL
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DOI：
10.1016/0168-8278(91)90873-a
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发表时间：
1991-07-01
影响因子：
25.7
通讯作者：
WILLIAMS, R
中科院分区：
文献类型：
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作者：
JOHNSON, PJ;KALAYCI, C;WILLIAMS, R
为了确定联合应用阿曲碘油对肝细胞癌患者动脉内阿霉素的药代动力学和全身毒性的影响，对9例患者进行了详细研究。每个人都接受了两个疗程的阿霉素（60 mg/m2）推注，其中一个疗程中阿霉素与10 ml阿曲库碘油混合。对配对数据和另外7名患者的“非配对”数据的分析表明，阿霉素或阿霉素的浓度-时间曲线下面积或阿霉素的终末半衰期无显著差异。同样，治疗后血红蛋白浓度、白色细胞计数和血小板计数的下降以及恶心和呕吐的程度也没有显著差异。与一系列的12例接受静脉注射阿霉素，在相同的剂量方案，显示没有差异的药代动力学参数或毒性与动脉注射阿霉素，有或没有阿曲碘油。
To determine the effect of coadministration of lipiodol on the pharmacokinetics and systemic toxicity of intraarterial Adriamycin in patients with hepatocellular carcinoma, nine patients were studied in detail. Each received two courses of a bolus injection of Adriamycin (60 mg/m2), in one of which the Adriamycin was mixed with 10 ml of lipiodol. Analysis of the paired data, and additional 'non-paired' data from a further seven patients, showed that there was no significant difference in the area under the concentration-time curve for Adriamycin or adriamycinol or, in the case of Adriamycin, the terminal half-life. Likewise the fall in haemoglobin concentration, white cell count and platelet count following treatment, and the degree of nausea and vomiting were not significantly different. Comparison with a series of 12 patients receiving intravenous Adriamycin, in the same dose schedule, revealed no difference in terms of pharmacokinetic parameters or toxicity with intraarterial administration of Adriamycin, with or without lipiodol.