Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans
Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans
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DOI：
10.1038/ijo.2009.159
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发表时间：
2009-11-01
影响因子：
4.9
通讯作者：
Sorensen, T. I. A.
中科院分区：
文献类型：
--
作者：
Grau, K.;Hansen, T.;Sorensen, T. I. A.
背景资料：目的：检测FTO rs 9939609是否影响肥胖个体对高脂肪、低碳水化合物（CHO）（HF）或低脂、高CHO（LF）、低能量饮食的反应，以及FTO变体的影响是否取决于膳食脂肪和CHO含量。设计：在一项为期10周的欧洲多中心饮食干预研究中，771名肥胖女性和男性被随机分配至LF（20-25%的能量（%E）来自脂肪，60-65%的E来自CHO）或HF（40 - 45%的E来自脂肪，40-45%的E来自CHO），低能量饮食（测量的静息代谢率乘以1.3-600 kcal/天（-1））。在基线和干预后测量体重、脂肪质量（FM）、去脂肪质量（FFM）、腰围（WC）、静息能量消耗（REE）、空腹脂肪氧化占REE的百分比（FatOx）、胰岛素释放（HOMA-beta）和胰岛素抵抗的替代指标（HOMA-IR）。结果：对于A等位基因携带者，HF组的脱落率高于LF组（AT组，P = 0.002; AT/AA组，P = 0.003）。在完成干预的那些个体中，我们发现FTO rs 9939609基因型对Delta体重、Delta FM、Delta FFM、Delta WC或Delta FatOx没有影响。然而，TT参与者LF的REE降低幅度小于HF饮食（75 kcal/24 h;相互作用：P = 0.0055）。这些个体也表现出HOMA-beta和HOMA-IR的最大降低结论：FTO rs 9939609可能与减肥饮食中的大量营养素组成以多种方式相互作用; LF饮食的A等位基因携带者似乎有较低的辍学风险，与HF组相比，TT组的REE下降幅度较小，HOMA-IR和HOMA-beta下降幅度较大。International Journal of Obesity（2009）33，1227-1234; doi：10.1038/ijo.2009.159; 2009年8月18日在线发表
Background: The A risk allele of rs9939609 of the fat mass- and obesity-associated gene (FTO) increases body fat mass.Objective: To examine whether FTO rs9939609 affects obese individuals' response to a high-fat, low-carbohydrate (CHO) (HF) or low-fat, high-CHO (LF), hypo-energetic diet and whether the effect of the FTO variant depends on dietary fat and CHO content.Design: In a 10-week, European, multi-centre dietary intervention study 771 obese women and men were randomized to either LF (20-25% of energy (%E) from fat, 60-65% E from CHO) or HF (40-45% E from fat, 40-45% E from CHO), hypo-energetic diet (measured resting metabolic rate multiplied by 1.3-600 kcal day(-1)). Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation as % of REE (FatOx), insulin release (HOMA-beta) and a surrogate measure of insulin resistance (HOMA-IR) were measured at baseline and after the intervention. In all, 764 individuals were genotyped for FTO rs9939609.Results: For A-allele carriers the drop-out rate was higher on HF than LF diet (in AT, P = 0.002; in AT/AA combined, P = 0.003). Among those individuals completing the intervention, we found no effect of FTO rs9939609 genotype on Delta weight, Delta FM, Delta FFM, Delta WC or Delta FatOx. However, participants with TT had a smaller reduction in REE on LF than on HF diet (75 kcal/24 h; interaction: P = 0.0055). These individuals also showed the greatest reduction in HOMA-beta and HOMA-IR (interaction: P = 0.0083 and P = 0.047).Conclusion: The FTO rs9939609 may interact with the macronutrient composition in weight loss diets in various ways; carriers of the A allele on LF diet appear to have a lower risk for drop out, and TT individuals have a smaller decrease in REE and greater decrease in HOMA-beta and HOMA-IR on LF than on HF diet. International Journal of Obesity (2009) 33, 1227-1234; doi:10.1038/ijo.2009.159; published online 18 August 2009