Incorporating basic nutrition science into health interventions for cancer prevention.
Incorporating basic nutrition science into health interventions for cancer prevention.
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将基础营养科学纳入癌症预防的健康干预措施。
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
J. Milner
中科院分区：
文献类型：
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作者：
J. Milner
越来越多的证据表明，许多饮食成分可以改变癌症的发病率以及肿瘤的生物学行为。这些抑制或刺激作用不仅取决于所检查的膳食成分，还取决于许多因素，包括细胞DNA谱（营养遗传学和营养基因组学效应）、蛋白质形成和调节（蛋白质组学效应）以及活性中间体在特定靶位点的有效递送（代谢组学效应）。不幸的是，饮食和癌症研究领域充斥着设计不充分的研究，以监测生物学终点，使用无效的生物标志物，或监测不相关的摄入量或暴露量。随着可靠的营养和癌症生物标志物数据库的建立，健康风险预测和疾病预防策略的科学前沿将大大扩展，这些数据库使用建模技术来整合有关摄入量，效应生物标志物和易感性生物标志物的信息。该数据库的基础是阐明特定饮食成分的特定分子作用位点（靶点）。将需要建立在基因或基因表达或其产物的比率上的聚类技术来评估特定饮食干预的优点。关于饮食诱导的基因及其表达产物波动如何改变与致癌物激活和解毒相关的途径、改变细胞增殖速率、影响细胞凋亡和改变血管生成的模型已经浮出水面。采用新的基因组技术为促进营养提供了令人兴奋的机会，特别是与癌症预防有关的营养。我们必须在一个负责任的生物伦理框架内有效地宣传有关基因和基因产品的知识的潜在价值。
Increasing evidence points to numerous dietary components that modify cancer incidence as well as the biological behavior of tumors. These inhibitory or stimulatory effects depend not only on the dietary component examined, but on a number of factors including the cellular DNA profile (nutrigenetic and nutrigenomic effects), protein formation and regulation (proteomic effect), and the effective delivery of the active intermediate at specific target sites (metabolomic effect). Unfortunately, the diet and cancer research domain is strewn with studies that were inadequately designed to monitor biological endpoints, used invalid biomarkers, or monitored irrelevant intakes or exposures. The scientific frontiers in health risk prediction and disease prevention strategies will greatly expand with the building of reliable nutrition and cancer biomarker databases that use modeling techniques to integrate information about intakes, effect biomarkers, and susceptibility biomarkers. Fundamental to this database will be the elucidation of the specific molecular sites of action (targets) for the specific dietary component. Clustering techniques that build on either genes or ratios of genetic expressions or their products will be needed to assess the merit of a particular dietary intervention. Models are already surfacing about how dietary-induced fluctuations in genes and their expression products can modify pathways associated with carcinogen activation and detoxification, alter rates of cellular proliferation, influence apoptosis, and modify angiogenesis. Embracing new genomic technologies offers exciting opportunities for advancing nutrition, especially those related to cancer prevention. We must effectively communicate, within a responsible bioethical framework, the potential value of knowledge about genes and gene products.
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影响因子：
11.2
作者：
Weiqin Jiang;Zongjian Zhu;H. Thompson
通讯作者：
Weiqin Jiang;Zongjian Zhu;H. Thompson
影响因子：
11.2
作者：
W. Yang;J. Mathew;A. Velcich;W. Edelmann;R. Kucherlapati;M. Lipkin;K. Yang;L. Augenlicht
通讯作者：
W. Yang;J. Mathew;A. Velcich;W. Edelmann;R. Kucherlapati;M. Lipkin;K. Yang;L. Augenlicht
针对黄曲霉毒素诱导的肝癌发生的化学保护反应的个体差异：对人类生物转化酶多态性的影响。
影响因子：
--
作者：
Eaton,DL;Bammler,TK;Kelly,EJ
通讯作者：
Kelly,EJ
影响因子：
4.7
作者：
Ravn-Haren, G;Olsen, A;Vogel, U
通讯作者：
Vogel, U
影响因子：
4.2
作者：
Xu, J;Cho, H;Clarke, SD
通讯作者：
Clarke, SD