Serum Levels of Complement-C1q/Tumor Necrosis Factor-Related Protein-3 Decreased in Patients With Acute Aortic Dissection
Serum Levels of Complement-C1q/Tumor Necrosis Factor-Related Protein-3 Decreased in Patients With Acute Aortic Dissection
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DOI：
10.1016/j.amjcard.2018.06.024
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发表时间：
2018-10-01
影响因子：
2.8
通讯作者：
Wan, Jun
中科院分区：
文献类型：
--
作者：
Jiang, Huimin;Wang, Menglong;Wan, Jun
补体C1 q/肿瘤坏死因子相关蛋白3（CTRP 3）是一种脂肪细胞因子，通过调节炎症反应在多种心血管疾病中发挥重要作用。据报道，炎症与急性主动脉夹层（AAD）的发生有关。本研究的目的是研究CTRP 3血清水平是否与AAD相关。108名受试者，包括60名AAD患者和32名高血压患者，以及16名健康受试者。使用酶联免疫吸附测定试剂盒测量CTRP 3、白细胞介素-6（IL-6）和肿瘤坏死因子（TNF-α）的血清水平。与高血压和健康受试者相比，AAD患者的CTRP 3血清水平降低（分别为35.89 +/- 11.26 vs 52.60 +/- 13.90和51.71 +/- 18.64 ng/mL，p < 0.001）。AAD患者IL-6和TNF-α水平显著高于高血压患者和健康人（IL-6：31.33 +/- 15.18 vs 13.13 +/- 8.63和9.40 +/- 6.27 pg/mL，p < 0.001; TNF-α：分别为36.87 +/- 11.16 vs 29.66 +/- 5.12和22.93 +/- 7.18 pg/mL，p < 0.001）。在AAD中，CTRP 3水平分别与IL-6和TNF-α水平呈负相关（分别为r = 0.508，p < 0.001; r = 0.393，p = 0.002）。总之，CTRP 3水平降低可能与AAD的发生有关。(C)2018爱思唯尔公司All rights reserved.
Complement-C1q/tumor necrosis factor-related protein-3 (CTRP3) is one kind of adipocytokines and has been reported to play key roles in many cardiovascular diseases by regulating inflammation. Inflammation was reported to be involved in the development of acute aortic dissection (AAD). The purpose of this study was to investigate whether serum levels of CTRP3 were associated with AAD. The serum was collected from 108 participants, including 60 patients with AAD and 32 patients with hypertension, as well as 16 healthy subjects. Serum levels of CTRP3, interleukin-6 (IL-6), and tumor necrosis factor(TNF-alpha) were measured using enzyme-linked immunosorbent assay kits. Decreased serum levels of CTRP3 were found in AAD patients compared with hypertension and healthy subjects (35.89 +/- 11.26 vs 52.60 +/- 13.90 and 51.71 +/- 18.64 ng/mL, p < 0.001, respectively). IL-6 and TNF-alpha levels were significantly higher in AAD patients than those in hypertension and healthy subjects (IL-6: 31.33 +/- 15.18 vs 13.13 +/- 8.63 and 9.40 +/- 6.27 pg/mL, p < 0.001; TNF-alpha: 36.87 +/- 11.16 vs 29.66 +/- 5.12 and 22.93 +/- 7.18 pg/mL, p < 0.001, respectively). In AAD, CTRP3 levels showed a negative correlation with IL-6 and TNF-alpha levels respectively (r = 0.508, p < 0.001; r = 0.393, p = 0.002, respectively). In conclusion, decreased levels of CTRP3 may be associated with the development of AAD. (C) 2018 Elsevier Inc. All rights reserved.