Early effects of ionizing radiation on the microvascular networks in normal tissue
Early effects of ionizing radiation on the microvascular networks in normal tissue
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DOI：
10.2307/3579938
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发表时间：
1999-03-01
影响因子：
3.4
通讯作者：
Kiani, MF
中科院分区：
文献类型：
--
作者：
Roth, NM;Sontag, MR;Kiani, MF
微血管网是血管系统中对电离辐射最敏感的部分，它控制着氧和营养物质的输送以及代谢废物的排出。本文研究了局部照射（单次10-GS剂量）后3、7和30天仓鼠提睾肌微血管网的结构和功能变化。参照组织中明确定义的位置选择网络，以减少由于空间变化引起的异质性。活体显微镜用于测量体内结构和功能参数。采用析因设计研究辐射状态、辐射后时间和血管网类型对微血管网结构和功能的影响。对照组动物的微血管直径随年龄增长而显著增加，而辐照血管的血管直径随年龄增长而显著下降。在照射后3天和30天，照射网络中的红细胞速度显着低于对照网络。结果表明：照射后血管毛细血管表面积明显减少，血细胞比容明显增加，血流量明显低于对照组，血管功能参数在照射后3天明显改变，而结构参数的改变出现在照射后3天。在每次检查时，所有血管类型均未受到同等程度的辐射损伤，（C）1999年，辐射研究学会。
Microvascular networks, which control the delivery of oxygen and nutrients and the removal of metabolic waste, are the most sensitive part of the vascular system to ionizing radiation, Structural and functional changes in microvascular networks were studied in locally irradiated (single 10-GS dose) hamster cremaster muscles observed 3, 7 and 30 days postirradiation. Networks were selected in reference to a well-defined location in the tissue to reduce heterogeneity due to spatial variations. Intravital microscopy was used to measure structural and functional parameters in vivo. A factorial design was used to examine the effects of radiation status, time postirradiation, and network vessel type on the structure and function of microvascular network. While the diameter of microvessels in control animals increased significantly with age, vessel diameter in irradiated vessels decreased significantly with age. Red blood cell velocity in irradiated networks at 3 and 30 days postirradiation was significantly lower than in control networks. There was a significant decrease in capillary surface area and a significant increase in vessel hematocrit in irradiated animals, Blood dow in irradiated vessels was significantly lower than in control vessels, Changes in functional parameters were evident at 3 days postirradiation while changes in structural parameters occurred later. All vessel types were not damaged equally by radiation at every time examined, (C) 1999 by Radiation Research Society.