Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2.
Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2.
复制标题
人热休克蛋白 40 (Hsp40) 基因 (HSPF1) 的基因组克隆及其染色体定位至 19p13.2。
作者：
M. Hata;K. Okumura;M. Seto;K. Ohtsuka
Hsp40（热休克蛋白，分子大小约为40 kDa）是细菌DnaJ热休克蛋白的哺乳动物同源物之一。我们已经分离并鉴定了一个包含人类Hsp40 cDNA全部编码序列的基因组DNA克隆。Hsp40基因（hgmw批准的符号HSPF1）由三个外显子和两个内含子组成。该基因的5′区富含GC，转录因子的基础元件较多，包括典型的热休克元件。Hsp40基因通过原位杂交被定位到19号染色体p13.2带。
The Hsp40 (heat shock protein with molecular size of approximately 40 kDa) is one of the mammalian homologues of bacterial DnaJ heat shock protein. We have isolated and characterized a genomic DNA clone encompassing the entire coding sequences of the human Hsp40 cDNA. The Hsp40 gene (HGMW-approved symbol HSPF1) is composed of three exons divided by two introns. The 5' region of the gene is highly GC rich, and there are multiple basal elements for transcription factors including typical heat shock elements. The Hsp40 gene has been assigned to chromosome 19 band p13.2 by in situ hybridization.