Treatment of microvascular micro-embolization using microbubbles and long-tone-burst ultrasound: an in vivo study.
Treatment of microvascular micro-embolization using microbubbles and long-tone-burst ultrasound: an in vivo study.
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使用微泡和长色 - 爆破超声处理微血管微栓塞：一项体内研究。
DOI：
10.1016/j.ultrasmedbio.2014.09.033
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发表时间：
2015-02
影响因子：
2.9
通讯作者：
Villanueva, Flordeliza S.
中科院分区：
文献类型：
--
作者：
Pacella, John J.;Brands, Judith;Schnatz, Frederick G.;Black, John J.;Chen, Xucai;Villanueva, Flordeliza S.
Despite epicardial coronary artery reperfusion by percutaneous coronary intervention, distal micro-embolization into the coronary microcirculation limits myocardial salvage during acute myocardial infarction. Thrombolysis using ultrasound and microbubbles (sonothrombolysis) is an approach that induces microbubble oscillations to cause clot disruption and restore perfusion. We sought to determine whether this technique could restore impaired tissue perfusion caused by thrombotic microvascular obstruction. In 16 rats, an imaging transducer was placed on the biceps femoris muscle, perpendicular to a single-element 1-MHz treatment transducer. Ultrasound contrast perfusion imaging was performed at baseline and after micro-embolization. Therapeutic ultrasound (5000 cycles, pulse repetition frequency = 5 0.33 Hz, 1.5 MPa) was delivered to nine rats for two 10-min sessions during intra-arterial infusion of lipid-encapsulated microbubbles; seven control rats received no ultrasound–microbubble therapy. Ultrasound contrast perfusion imaging was repeated after each treatment or control period, and microvascular volume was measured as peak video intensity. There was a 90% decrease in video intensity after micro-embolization (from 8.6 ± 4.8 to 0.7 ± 0.8 dB, p < 0.01). The first and second ultrasound–microbubble sessions were respectively followed by video intensity increases of 5.8 ± 5.1 and 8.7 ± 5.7 dB (p < 0.01, compared with micro-embolization). The first and second control sessions, respectively, resulted in no significant increase in video intensity (2.4 ± 2.3 and 3.6 ± 4.9) compared with micro-embolization (0.6 ± 0.7 dB). We have developed an in vivo model that simulates the distal thrombotic microvascular obstruction that occurs after primary percutaneous coronary intervention. Long-pulse-length ultrasound with microbubbles has a therapeutic effect on microvascular perfusion and may be a valuable adjunct to reperfusion therapy for acute myocardial infarction.
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影响因子：
8.3
作者：
Culp WC;Flores R;Brown AT;Lowery JD;Roberson PK;Hennings LJ;Woods SD;Hatton JH;Culp BC;Skinner RD;Borrelli MJ
通讯作者：
Borrelli MJ
影响因子：
37.8
作者：
Birnbaum, Y;Luo, H;Siegel, RJ
通讯作者：
Siegel, RJ
影响因子：
3.2
作者：
Isshiki, Takaaki;Kozuma, Ken;Yamamoto, Yoshito
通讯作者：
Yamamoto, Yoshito
DOI：
10.1016/s0967-2109(98)00097-0
发表时间：
1999-01-01
期刊：
CARDIOVASCULAR SURGERY
影响因子：
--
作者：
Jordan, WD;Voellinger, DC;McDowell, HA
通讯作者：
McDowell, HA
影响因子：
24
作者：
Montorsi, Piero;Caputi, Luigi;Bartorelli, Antonio L.
通讯作者：
Bartorelli, Antonio L.