Selected PET radiomic features remain the same.
Selected PET radiomic features remain the same.
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DOI：
10.18632/oncotarget.25070
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发表时间：
2018-04-17
期刊：
影响因子：
--
通讯作者：
Okazawa H
中科院分区：
文献类型：
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作者：
Tsujikawa T;Tsuyoshi H;Kanno M;Yamada S;Kobayashi M;Narita N;Kimura H;Fujieda S;Yoshida Y;Okazawa H
我们使用18F-FDG PET/CT和PET/MR扫描研究了PET放射学特征是否受到扫描仪、扫描方案和病变位置的差异的影响。SUV， TMR，偏度，峰度，熵和均匀性在PET/CT和PET/MR图像之间具有很强的相关性。妇科肿瘤的PET/MR0-2 min和PET/MR0-10 min上的suv明显高于PET/CT (p分别为0.008和0.008)，而口腔/口咽癌的PET/CT、PET/MR0-2 min和PET/MR0-10 min影像间差异无统计学意义。在妇科癌和口腔/口咽癌中，PET/CT tmr、PET/ MR0-2 min和PET/ MR0-10 min依次升高。与常规和直方图指数相比，PET/CT、PET/ MR0-2分钟和PET/ MR0-10分钟图像的4个纹理特征（熵、均匀性、SRE和LRE）无显著差异。18F-FDG PET放射学特征在PET/CT和PET/MR图像之间具有很强的相关性。PET/MR图像中基于dison的衰减校正明显低估了口腔/口咽癌的肿瘤示踪剂摄取。与传统和直方图特征相比，18F-FDG PET纹理特征受扫描仪和扫描协议差异的影响较小，这可能是由于使用中等箱宽的重采样过程。8例妇科癌患者和7例口腔/口咽癌患者在1天内进行了全身18F-FDG PET/CT扫描和局部PET/MR扫描。在列表模式下进行10分钟的PET/MR扫描，重建PET/CT和0-2分钟、0-10分钟的PET/MR图像。比较PET/CT、PET/MR0-2 min和PET/MR0-10 min图像的标准化摄取值（SUV）、肿瘤与肌肉的SUV比（TMR）、偏度、峰度、熵、均匀性、短期重点（SRE）和长期重点（LRE）。
We investigated whether PET radiomic features are affected by differences in the scanner, scan protocol, and lesion location using 18F-FDG PET/CT and PET/MR scans. SUV, TMR, skewness, kurtosis, entropy, and homogeneity strongly correlated between PET/CT and PET/MR images. SUVs were significantly higher on PET/MR0-2 min and PET/MR0-10 min than on PET/CT in gynecological cancer (p = 0.008 and 0.008, respectively), whereas no significant difference was observed between PET/CT, PET/MR0–2 min, and PET/MR0–10 min images in oral cavity/oropharyngeal cancer. TMRs on PET/CT, PET/MR0–2 min, and PET/MR0–10 min increased in this order in gynecological cancer and oral cavity/oropharyngeal cancer. In contrast to conventional and histogram indices, 4 textural features (entropy, homogeneity, SRE, and LRE) were not significantly different between PET/CT, PET/MR0–2 min, and PET/MR0–10 min images. 18F-FDG PET radiomic features strongly correlated between PET/CT and PET/MR images. Dixon-based attenuation correction on PET/MR images underestimated tumor tracer uptake more significantly in oral cavity/oropharyngeal cancer than in gynecological cancer. 18F-FDG PET textural features were affected less by differences in the scanner and scan protocol than conventional and histogram features, possibly due to the resampling process using a medium bin width. Eight patients with gynecological cancer and 7 with oral cavity/oropharyngeal cancer underwent a whole-body 18F-FDG PET/CT scan and regional PET/MR scan in one day. PET/MR scans were performed for 10 minutes in the list mode, and PET/CT and 0–2 min and 0–10 min PET/MR images were reconstructed. The standardized uptake value (SUV), tumor-to-muscle SUV ratio (TMR), skewness, kurtosis, entropy, homogeneity, short-run emphasis (SRE), and long-run emphasis (LRE) were compared between PET/CT, PET/MR0-2 min, and PET/MR0-10 min images.