Correlations of polymorphisms in matrix metalloproteinase-1, -2, and -7 promoters to susceptibility to malignant gliomas.
Correlations of polymorphisms in matrix metalloproteinase-1, -2, and -7 promoters to susceptibility to malignant gliomas.
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基质金属蛋白酶-1，-2和-7启动子对恶性神经胶质瘤的敏感性的多态性相关性。
DOI：
10.4103/1793-5482.145338
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Ojha B
中科院分区：
文献类型：
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作者：
Kawal P;Chandra A;Rajkumar;Dhole TN;Ojha B
少突胶质细胞瘤是浸润性星形细胞肿瘤。它们约占颅内肿瘤的 1-5%。这些已被分为良性和恶性等级。 MMP基因启动子区的单核苷酸多态性(SNP)可能影响肿瘤的发生和进展。本研究旨在探讨MMP-1、MMP-2和MMP-7基因的启动子SNP与少突胶质细胞瘤发生和进展的易感性的相关性。我们的目的是研究 MMP1 (−1607A > G)、MMP-2 (−1306 C/T) 和 MMP-7 (−181A > G) 基因多态性在少突胶质细胞瘤（I、II、III 级）中的关联。在本病例对照研究中，我们共纳入30例经组织病理学证实的少突胶质细胞瘤（I至III级）病例和30例健康病例作为对照。通过限制性片段长度多态性对MMP-1基因(-1607A>G)、MMP-2(-1306C/T)、MMP-7(-181A>G)的多态性进行基因分型。与健康对照 (13%) 相比，MMP-1 (−1607A > G) 基因型和 2G 等位基因的频率与少突神经胶质瘤病例 (30%) 显着相关。 [或= 6.89； P=0.02； 95%CI=(1.33-35.62)]和[OR=2.66； P=0.01； 95% CI=(1.26-5.64)]。未发现 MMP-2 (-1306C/T) 多态性与少突胶质细胞瘤显着相关 (P = 0.54)，表明 MMP-2 (-1306C/T) 多态性与少突胶质细胞瘤易感性增加无关。与健康对照 (13.33%) 相比，MMP-7(−181A > G) 基因型和 2G 等位基因的频率与少突神经胶质瘤病例 (33.33%) 显着相关。 [或= 5.65； P=0.02； 95%CI=(1.26-25.36)]和[OR=2.49； P=0.01； 95% CI=(1.17-5.27)]。 MMP-1 (−1607 A > G)、MMP-7(−181A > G) 基因型和 2G 等位基因与少突胶质细胞瘤（I、II、III 级）显着相关，但 MMP-2 (−1306C/T) 多态性与少突胶质细胞瘤易感性增加无关。
Oligodendrogliomas are infiltrative astrocytic tumors. They constitute about 1-5% of intracranial tumors. These have been graded into benign and malignant grades. The single nucleotide polymorphisms (SNPs) in the promoter regions of MMP genes may influence tumor development and progression. This study was done to explore the correlations of the promoter SNPs in MMP-1, MMP-2 and MMP-7 genes susceptibility in development and progression of oligodendrogliomas. We aimed to investigate the association of MMP1 (−1607A > G), MMP-2 (−1306 C/T) and MMP-7(−181A > G) gene polymorphism in oligodendrogliomas (grade I, II, III). In the present case control study, we enrolled a total of 30 cases of oligodendrogliomas (grade I to III) confirmed by histopathology and 30 healthy cases as control. Polymorphism for MMP-1 gene (−1607A > G), MMP-2 (−1306 C/T), MMP-7(−181A > G) were genotyped by restriction fragment length polymorphism. Frequencies of MMP-1 (−1607A > G) genotypes and 2G alleles were significantly associated with the cases of oligodendrogliomas (30%) in relation to healthy controls (13%). [OR = 6.89; P = 0.02; 95%CI= (1.33-35.62)] and [OR = 2.66; P =0.01; 95% CI= (1.26-5.64)]. A significant association of MMP-2 (−1306C/T) polymorphism with oligodendroglioma (P = 0.54) was not found, suggesting that MMP-2 (−1306C/T) polymorphism is not associated with increased oligodendroglioma susceptibility. Frequencies of MMP-7(−181A > G) genotypes and 2G alleles were significantly associated with the cases of oligodendrogliomas (33.33%) in relation to healthy controls (13.33%). [OR = 5.65; P = 0.02; 95%CI= (1.26-25.36)] and [OR = 2.49; P =0.01; 95% CI= (1.17-5.27)]. MMP-1 (−1607 A > G), MMP-7(−181A > G) genotypes and 2G alleles were significantly associated with oligodendroglioma (grade I, II, III), but MMP-2 (−1306C/T) polymorphism is not associated with increased oligodendroglioma susceptibility.