Age of ovary determines remaining life expectancy in old ovariectomized mice
Age of ovary determines remaining life expectancy in old ovariectomized mice
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DOI：
10.1046/j.1474-9728.2003.00049.x
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发表时间：
2003-06-01
期刊：
影响因子：
7.8
通讯作者：
Anderson, G
中科院分区：
文献类型：
--
作者：
Cargill, SL;Carey, JR;Anderson, G
我们研究了年轻的卵巢，移植到老年卵巢切除CBA小鼠，以提高剩余寿命的主机的能力。供体雌性是性成熟的2个月大;受体在3周时进行青春期前卵巢切除术，并在5、8或11个月大时接受移植。相对于卵巢切除的对照组雌性，11个月时的预期寿命在11个月的受体雌性中增加60%，相对于完整的对照组雌性增加40%。在卵巢移植后的300天内，只有20%的11个月移植雌性动物死亡，而在同一时期，近65%的卵巢切除对照雌性动物死亡。11个月大的受体雌性恢复发情，并继续循环长达几个月，超过对照雌性生殖衰老的年龄。在三个受体年龄组中，移植年轻卵巢与卵巢相对年轻成比例地增加了预期寿命。我们的研究结果与最近的研究结果在秀丽隐杆线虫老化后的性腺输入，并可能表明如何哺乳动物的性腺，包括人类，可以调节衰老和决定寿命。
We investigated the capacity of young ovaries, transplanted into old ovariectomized CBA mice, to improve remaining life expectancy of the hosts. Donor females were sexually mature 2-month-olds; recipients were prepubertally ovariectomized at 3 weeks and received transplants at 5, 8 or 11 months of age. Relative to ovariectomized control females, life expectancy at 11 months was increased by 60% in 11-month recipient females and by 40% relative to intact control females. Only 20% of the 11-month transplant females died in the 300-day period following ovarian transplantation, whereas nearly 65% of the ovariectomized control females died during this same period. The 11-month-old recipient females resumed oestrus and continued to cycle up to several months beyond the age of control female reproductive senescence. Across the three recipient age groups, transplantation of young ovaries increased life expectancy in proportion to the relative youth of the ovary. Our results relate to recent findings on the gonadal input upon aging in Caenorhabditis elegans and may suggest how the mammalian gonad, including that of humans, could regulate aging and determine longevity.