Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure
Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure
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DOI：
10.1016/j.bbi.2005.05.005
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发表时间：
2006-03-01
影响因子：
15.1
通讯作者：
Cohen, S
中科院分区：
文献类型：
--
作者：
Doyle, WJ;Gentile, DA;Cohen, S
社会心理因素会调节上呼吸道病毒感染期间疾病的表现，但以往确定中介途径的尝试并不成功。在此，我们利用人类鼻病毒实验感染模型来评估三种促炎细胞因子在介导先前记录的积极情绪类型与疾病之间关联方面的潜在作用。在对327名健康成年人的情绪类型进行评估后，每人接触两种鼻病毒株中的一种，并在隔离状态下观察5天。在基线以及接触后的5天中每天都对症状/体征、鼻腔灌洗液中的白细胞介素 - 1β、白细胞介素 - 6和白细胞介素 - 8蛋白以及病毒排出情况进行评估。在基线以及激发后28天对病毒特异性抗体进行评估。对234名有记录感染的受试者的数据进行分析表明，鼻腔白细胞介素 - 1β、白细胞介素 - 6和白细胞介素 - 8蛋白水平都与更严重的疾病表现有关，但白细胞介素 - 6是迄今为止鼻腔症状和体征的最佳预测因子。较低的积极情绪类型与更严重的疾病客观和主观指标相关，通过控制白细胞介素 - 6，这些关联大幅降低，但控制白细胞介素 - 1β或白细胞介素 - 8时则不然。这些结果与白细胞介素 - 6在鼻病毒感染期间作为将积极情绪类型与疾病表现联系起来的生物中介这一假设相符。(c) 2005爱思唯尔公司。保留所有权利。
Psychosocial factors moderate the expression of illness during upper respiratory virus infections but past attempts to define mediational pathways were not successful. Here, we used a model of experimental rhinovirus infection in humans to evaluate three proinflammatory cytokines for their potential role in mediating the previously documented association between positive emotional style and illness. After assessing emotional style in 327 healthy adults, each was exposed to one of two strains of rhinovirus and followed for 5 days in quarantine. Symptoms/signs, nasal lavage IL-1 beta, IL-6, and IL-8 protein, and viral shedding were assessed at baseline and on each of the 5 days after exposure. Virus-specific antibody was assessed at baseline and 28 days after challenge. An analysis of the data for 234 subjects with documented infection showed that nasal IL-1 beta, IL-6, and IL-8 protein levels were all associated with greater illness expression but IL-6 was by far the best predictor of nasal signs and symptoms. Lower positive emotional style was associated with greater objective and subjective markers of illness and these associations were decreased substantially by controlling for IL-6 but not for IL-1 beta or IL-8. These results are consistent with the hypothesis that IL-6 acts as a biological mediator in linking positive emotional style to illness expression during rhinovirus infection. (c) 2005 Elsevier Inc. All rights reserved.