Estimating 24-h urinary sodium/potassium ratio from casual ('spot') urinary sodium/potassium ratio: the INTERSALT Study.
Estimating 24-h urinary sodium/potassium ratio from casual ('spot') urinary sodium/potassium ratio: the INTERSALT Study.
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DOI：
10.1093/ije/dyw287
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发表时间：
2017-10-01
影响因子：
7.7
通讯作者：
INTERSALT Research Group
中科院分区：
文献类型：
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作者：
Iwahori T;Miura K;Ueshima H;Chan Q;Dyer AR;Elliott P;Stamler J;INTERSALT Research Group
偶然和24小时尿钠钾（Na/K）比值之间的关联是公认的，尽管它尚未在不同的人口统计学群体中得到验证。我们的目的是评估使用INTERSALT研究的数据在人群之间和人群内使用随意尿估计24小时尿Na/K比值的效用。INTERSALT研究收集了来自32个国家（1985-87年）52个人群样本的10065名个体的临时尿钠和钾以及定时24小时尿钠和钾的横断面标准化数据。皮尔森相关系数和协议计算的钠/钾比值的休闲尿对24小时尿钠/钾比值在人口和个人水平。在人群和个体分析中，与24小时尿和偶然尿Na/K比值相关的Pearson相关系数分别为r = 0.96和r = 0.69。在人群和个体分析中，偶然尿Na/肌酐和K/肌酐比值分别与24小时尿Na和K排泄的相关性低于偶然尿Na/K比值与24小时尿Na/K比值的相关性。Bland-Altman方法的偏倚估计值（定义为24小时尿液和非常规尿液的Na/K比值之间的差异）在人群和个体中均约为0.4。分散开来，个体的平均偏差高于群体。经过适当的偏倚校正，临时尿Na/K比值可能是一种有用的，低负担的替代方法，24小时尿估计人群尿Na/K比值。它也可用于评估个人的尿Na/K比值，使用重复测量，以减少测量误差，提高精度。
Association between casual and 24-h urinary sodium-to-potassium (Na/K) ratio is well recognized, although it has not been validated in diverse demographic groups. Our aim was to assess utility across and within populations of casual urine to estimate 24-h urinary Na/K ratio using data from the INTERSALT Study. The INTERSALT Study collected cross-sectional standardized data on casual urinary sodium and potassium and also on timed 24-h urinary sodium and potassium for 10 065 individuals from 52 population samples in 32 countries (1985–87). Pearson correlation coefficients and agreement were computed for Na/K ratio of casual urine against 24-h urinary Na/K ratio both at population and individual levels. Pearson correlation coefficients relating means of 24-h urine and casual urine Na/K ratio were r = 0.96 and r = 0.69 in analyses across populations and individuals, respectively. Correlations of casual urine Na/creatinine and K/creatinine ratios with 24-h urinary Na and K excretion, respectively, were lower than correlation of casual and 24-h urinary Na/K ratio in analyses across populations and individuals. The bias estimate with the Bland–Altman method, defined as the difference between Na/K ratio of 24-h urine and casual urine, was approximately 0.4 across both populations and individuals. Spread around, the mean bias was higher for individuals than populations. With appropriate bias correction, casual urine Na/K ratio may be a useful, low-burden alternative method to 24-h urine for estimation of population urinary Na/K ratio. It may also be applicable for assessment of the urinary Na/K ratio of individuals, with use of repeated measurements to reduce measurement error and increase precision.