Change of hemopexin level is associated with the severity of sepsis in endotoxemic rat model and the outcome of septic patients
Change of hemopexin level is associated with the severity of sepsis in endotoxemic rat model and the outcome of septic patients
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DOI：
10.1016/j.jcrc.2014.12.009
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发表时间：
2015-06-01
影响因子：
3.7
通讯作者：
Suh, Gil Joon
中科院分区：
文献类型：
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作者：
Jung, Jae Yun;Kwak, Young Ho;Suh, Gil Joon
目的：本研究的目的是揭示血红素结合蛋白（HPX）作为动物和人类抗炎介质的作用。 材料和方法：我们分别给大鼠注射5和10 mg/kg脂多糖以诱导低度和高度内毒素血症（LGE和HGE），并在0、1、3和6小时测量肿瘤坏死因子α、白细胞介素6和HPX的血清水平注射后。在一项临床研究中，我们测量了感染性休克患者的初始血清 HPX 浓度。我们评估了大鼠 HPX 水平与脓毒症严重程度之间的相关性以及 HPX 水平对患者 28 天死亡率的预测价值。 结果：在大鼠中，LGE 中的血清白细胞介素 6 和肿瘤坏死因子 a 浓度低于 HGE 中，而 6 小时时 HGE 中的 HPX 水平显着低于 LGE 中（0.88，四分位距 [0.79-1.00] vs 1.33，四分位距） [1.29-1.49] 毫克/毫升，P = .002）。在患者中，非幸存者的初始血清 HPX 水平显着低于幸存者（0.75 vs 1.02 mg/mL，P
Purpose: The purpose of the study is to uncover the role of hemopexin (HPX) as anti- inflammatory mediator in animals and humans.Materials and methods: We injected rats with 5 and 10 mg/kg of lipopolysaccharide to induce low-and high-grade endotoxemia (LGE and HGE), respectively, and we measured serum levels of tumor necrosis factor alpha, interleukin 6, and HPX at 0, 1, 3, and 6 hours after the injection. In a clinical study, we measured the initial serum HPX concentrations of septic shock patients. We evaluated the correlation between HPX levels and sepsis severity in rats and the predictive value of the HPX level for 28-day mortality of patients.Results: In rats, serum interleukin 6 and tumor necrosis factor a concentrations were lower in LGE than in HGE, whereas the HPX level in HGE at 6 hours was significantly lower than in LGE (0.88, interquartile range [0.79-1.00] vs 1.33, interquartile range [1.29-1.49] mg/mL, P = .002). In patients, the initial serum HPX level in nonsurvivors was significantly lower than in survivors (0.75 vs 1.02 mg/mL, P