Comparison of osteogenic potential between apatite-coated poly(lactide-co-glycolide)/hydroxyapatite particulates and Bio-Oss®
Comparison of osteogenic potential between apatite-coated poly(lactide-co-glycolide)/hydroxyapatite particulates and Bio-Oss®
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DOI：
10.4012/dmj.27.368
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发表时间：
2008-05-01
影响因子：
2.5
通讯作者：
Kim, Byung-Soo
中科院分区：
文献类型：
--
作者：
Kim, Sang-Soo;Kim, Byung-Soo
以前，我们开发了一种聚（丙交酯-共-乙交酯）/纳米羟基磷灰石（PLGA/HA）复合材料，克服了传统陶瓷骨替代物的局限性。这是通过在复合材料上引入骨样磷灰石层以进一步增强其成骨潜力来实现的。在这项研究中，我们比较了磷灰石涂层PLGA/HA颗粒与Bio-Oss（R）（一种脱蛋白牛骨材料）的成骨潜力。将纤维蛋白凝胶和磷灰石涂层的PLGA/HA颗粒或Bio-Oss（R）的混合物植入临界尺寸的大鼠颅骨缺损中。作为对照，将纤维蛋白凝胶单独植入缺损中。治疗后8周，组织学检查显示移植材料周围有新骨形成，两组之间的骨形成相似。对照组无骨再生，缺损处填充纤维组织。该研究表明，合成骨移植材料，磷灰石涂层PLGA/HA颗粒，具有与牛源性骨移植材料Bio-Oss（R）相当的骨再生潜力。
Previously, we developed a poly(lactide-co-glycolide)/nano-hydroxyapatite (PLGA/HA) composite that overcame the limitations of conventional ceramic bone substitutes. This was achieved by introducing a bone-like apatite layer on the composite to further enhance its osteogenic potential. In this study, we compared the osteogenic potential of the apatite-coated PLGA/HA particulates to that of Bio-Oss (R), a deproteinized bovine bone material. A mixture of fibrin gel and either apatite-coated PLGA/HA particulates or Bio-Oss (R) was implanted into critical-size rat calvarial defects. As a control, fibrin gel was implanted alone into the defects. At eight weeks after treatment, histological examination showed new bone formation around the grafting materials, and bone formation was similar between the two groups. In the control group, bone was not regenerated and the defects were filled with fibrous tissues. This study showed that a synthetic bone graft material, apatite-coated PLGA/HA particulates, had a comparable bone regeneration potential to the bovine-derived bone graft material, Bio-Oss (R).