Changes in retinal thickness are correlated with alterations of electroretinogram in eyes with central retinal artery occlusion
Changes in retinal thickness are correlated with alterations of electroretinogram in eyes with central retinal artery occlusion
复制标题
DOI：
10.1007/s00417-008-0791-x
复制
发表时间：
2008-07-01
影响因子：
2.7
通讯作者：
Nakatsuka, Kazuo
中科院分区：
文献类型：
--
作者：
Shinoda, Kei;Yamada, Kisaburo;Nakatsuka, Kazuo
背景我们调查了视网膜中央动脉闭塞（CRAO）患者的视网膜厚度和视网膜电图（ERG）成分之间的关系。方法对9名患者（6名男性和3名女性；平均年龄61.8岁）的光学相干断层扫描（OCT）图像和ERG进行回顾性分析。在水平扫描的 OCT 图像中测量中央凹鼻部和颞部 1 毫米和 2 毫米处的内视网膜层和外视网膜层的厚度。计算内层厚度/感觉视网膜厚度的比率（IT/ST比率）。分析了混合杆锥 ERG 的 a 波和 b 波振幅以及明视 ERG 的明视负响应 (PhNR)。计算患眼与健侧眼各成分振幅之比（a/f比）。 结果 慢性期（发病后1～8个月，8只眼），内层明显薄于急性期（鼻部2 mm、鼻部1 mm、颞部1 mm、颞部2 mm分别P=0.0147、0.0076、0.002、0.0003，发病5天，6只眼），而外层厚度没有明显变化。 CRAO 发作后 6.4 +/- 1.5 天记录 ERG。 a/f 比的中位数在 a 波中为 0.84，在 b 波中为 0.56，在 PhNR 中为 0.27。慢性期IT/ST与PhNR振幅a/f比呈正相关。结论OCT测量视网膜厚度可用于监测CRAO后的变化。确定了视网膜厚度（尤其是内层厚度）与 ERG 成分之间的相关性，表明急性期的 PhNR 可能是预测慢性期受损视网膜变薄的良好指标。
Background We investigated the relationship between the retinal thickness and electroretinogram (ERG) components in patients with central retinal artery occlusion (CRAO).Methods The optical coherence tomographic (OCT) images and ERGs of the nine patients (six men and three women; mean age, 61.8 years) were retrospectively analyzed. The thickness of the inner and outer retinal layers at 1 and 2 mm nasal and temporal to the fovea was measured in the horizontally scanned OCT images. The ratio of the inner layer thickness/sensory retinal thickness (IT/ST ratio) was calculated. The amplitudes of the a- and b-waves of the mixed rod-cone ERGs and the photopic negative response (PhNR) of the photopic ERGs were analyzed. The ratio of the amplitude of each component in the affected eye to that of the healthy fellow eye (a/f ratio) was calculated.Results In the chronic phase (1 to 8 months after onset, eight eyes), the inner layer was significantly thinner than that in the acute phase (P=0.0147, 0.0076, 0.002, and 0.0003 for 2 mm nasal, 1 mm nasal, 1 mm temporal, and 2 mm temporal respectively, within 5 days of onset, six eyes), while the thickness of outer layer was not significantly changed. The ERGs were recorded 6.4 +/- 1.5 days after the onset of CRAO. The median of the a/f ratio was 0.84 in the a-wave, 0.56 in the b-wave, and 0.27 in the PhNR. The IT/ST in the chronic phase was positively correlated with the a/f ratio of the amplitude of the PhNR.Conclusions Measurement of retinal thickness by OCT can be useful for monitoring the changes following CRAO. The correlation between the retinal thickness, especially inner layer thickness, and the ERG components was determined, suggesting that the PhNR in the acute phase might be a good indicator for predicting the thinning of the damaged retina in the chronic phase.