Evaluation of 70-150-μm doxorubicin-eluting beads for transcatheter arterial chemoembolization in the rabbit liver VX2 tumour model.
Evaluation of 70-150-μm doxorubicin-eluting beads for transcatheter arterial chemoembolization in the rabbit liver VX2 tumour model.
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DOI：
10.1007/s00330-015-4197-y
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发表时间：
2016-10
影响因子：
5.9
通讯作者：
Liapi EA
中科院分区：
文献类型：
--
作者：
Gholamrezanezhad A;Mirpour S;Geschwind JF;Rao P;Loffroy R;Pellerin O;Liapi EA
评估兔肝 VX2 肿瘤模型动脉内注射 (i.a.) 后 70–150 µm 阿霉素洗脱珠 (DEB) 的药代动力学特征 (PK) 和栓塞效果。在这项经 ACUC 批准的研究中，25 只新西兰白兔被随机分为小 DEB 组（SDB，n=7，70–150μm DEB）、大 DEB 组（LDB，n=7，100–00μm DEB）、未经治疗的对照组（n=7）和多柔比星对照组（n=4，无肿瘤，接受 12.5 mg 多柔比星）。注射后 180 分钟内评估血浆 PK。 7 天时评估药物组织和肝酶水平、放射学肿瘤反应和组织病理学肿瘤坏死。 SDB 和 LDB 的平均肿瘤阿霉素浓度分别为 922.83nM (SD=722.05) 和 361.48nM (SD=473.23) (p=0.005)。肿瘤阿霉素、血浆阿霉素和阿霉素PK值无统计学差异。在 SDB 肿瘤中观察到更多的珠子 (p=0.01)。观察期间肝酶先升高后逐渐下降，SDB 值显着升高。在这项临床前研究中，i.a. 的血浆 PK注入的 70–150μm DEB 与 100–300μm DEB 没有什么不同。在 SDB 肿瘤中观察到更多的珠子和更高的组织阿霉素水平。
To evaluate the pharmacokinetic profile (PK) and embolization effect of 70–150µm doxorubicin eluting beads (DEB) following intra-arterial injection (i.a.) in the rabbit liver VX2 tumour model. In this ACUC approved study, 25 white New Zealand rabbits were randomly assigned into small DEB Group (SDB, n=7, 70–150µm DEB), large DEB Group (LDB, n=7, 100–00µm DEB), untreated controls (n=7), and doxorubicin controls (n=4, without tumour, received i.a. 12.5 mg doxorubicin). Plasma PK was assessed up to 180 min post-injection. Drug tissue and liver enzyme levels, radiologic tumor response and histopathologic tumour necrosis were assessed at 7 days. Mean tumour doxorubicin concentrations were 922.83nM (SD=722.05) and 361.48nM (SD= 473.23) for the SDB and LDB, respectively (p= 0.005). There was no statistically significant difference in tumour doxorubicinol, plasma doxorubicin and doxorubicinol PK values. More beads were observed in the SDB tumours (p=0.01). Liver enzymes increased and gradually declined over the observation period, with significantly higher values in the SDB. In this preclinical study, plasma PK of i.a. injected 70–150µm DEB was not different than that of 100–300µm DEB. More beads and higher tissue doxorubicin levels were observed in the SDB tumours.