Simultaneous measurement of hepatic and splenic stiffness using MR elastography: preliminary experience.

Simultaneous measurement of hepatic and splenic stiffness using MR elastography: preliminary experience.
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DOI:
10.1007/s00261-014-0255-1
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发表时间:
2015-04
期刊:
影响因子:
--
通讯作者:
Taouli, Bachir
Taouli, Bachir
中科院分区:
医学3区
文献类型:
--
作者:
Dyvorne, Hadrien A.;Jajamovich, Guido H.;Besa, Cecilia;Cooper, Nancy;Taouli, Bachir

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比较使用单驱动器激励和双驱动器激励量化肝脏和脾硬度(HS 和 SS)的 MR 弹性成像 (MRE),并研究使用单驱动器激励或双驱动器激励测量的 HS 和 SS 检测肝病受试者肝硬化的性能。这项符合 HIPAA 标准且 IRB 批准的前瞻性研究涉及 49 名接受 3.0T MRE 的受试者,比较了 3 种不同的采集方法(肝脏上的单驱动器、脾上的单驱动器和双驱动器声学激励)。曼-惠特尼测试用于评估刚度值的变化。 Bland-Altman 分析用于比较每个器官的单驱动器配置和双驱动器配置。使用 ROC 分析评估肝硬化检测的性能。使用 Pearson 相关性来估计 HS 和 SS 对脾脏大小的依赖性。有40名非肝硬化患者和9名肝硬化患者。使用单驱动器或双驱动器测得的刚度值之间具有良好的一致性(HS 和 SS 的 Bland-Altman 一致性限分别为 -14.3%–18.9% 和 -18.1%–29.7%,CV 6.4% 和 9.4%)。肝硬化受试者的 HS 和 SS 较高(p <0.001),具有出色的检测性能(AUROC 范围 0.87-0.93)。 SS 与脾脏大小密切相关(r=0.69,p<0.001),而 HS 表现出弱相关性(r=0.38,p=0.006)。使用双声学驱动器配置,可以同时估计肝脏和脾脏硬度,并且与单驱动器测量具有良好的一致性。
To compare MR elastography (MRE) using a single and a dual driver excitation for the quantification of hepatic and splenic stiffness (HS and SS), and to investigate the performance of HS and SS measured with single or dual driver excitation for the detection of liver cirrhosis in subjects with liver disease. This prospective HIPAA compliant and IRB approved study involved 49 subjects who underwent MRE at 3.0T, comparing 3 different acquisition methods (single driver on the liver, single driver on the spleen and dual driver acoustic excitation). A Mann-Whitney test was used to assess changes in stiffness values. Bland-Altman analysis was used to compare single and dual driver configurations for each organ. Performance for detection of liver cirrhosis was assessed using ROC analysis. Pearson correlation was used to estimate the dependence of HS and SS on spleen size. There were 40 noncirrhotic and 9 cirrhotic patients. There was good agreement between stiffness values measured with a single or a dual driver (Bland-Altman limits of agreement -14.3%–18.9 % and -18.1%–29.7 %, CV 6.4 % and 9.4 %, for HS and SS respectively). HS and SS were higher in subjects with liver cirrhosis (p <0.001), with excellent detection performance (AUROC range 0.87–0.93). SS correlated strongly with spleen size (r=0.69, p<0.001) while HS showed weak correlation (r=0.38, p=0.006). Using a dual acoustic driver configuration, hepatic and splenic stiffness can be simultaneously estimated with good concordance with single driver measurement.
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