The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens.
The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens.
复制标题
DOI：
10.1186/s40348-016-0041-y
复制
发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Naim HY
中科院分区：
文献类型：
--
作者：
Zeitouni NE;Chotikatum S;von Köckritz-Blickwede M;Naim HY
人体组织中氧稳态的维持是由几种细胞适应低氧应激（称为缺氧）介导的。组织氧水平的降低最初通过增加局部血流来抵消，以克服氧合减少并避免缺氧应激。然而，研究表明，几种组织中的生理氧浓度远低于大气（常氧）条件，并且氧供应在单个细胞类型中受到精细调节。胃肠道被描述为在生理低氧水平的状态下生存，因此被描述为处于持续低度炎症状态的组织。肠上皮细胞层在对肠组织内发生的炎症和感染的免疫应答中起着至关重要的作用，并且参与对缺氧应激的许多适应性应答。这在炎性疾病如炎性肠病（IBD）的情况下尤其相关。因此，本文综述的目的是描述肠上皮细胞对缺氧的反应和宿主与入侵的胃肠道细菌病原体相互作用的后果。
The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted by increasing local blood flow to overcome diminished oxygenation and avoid hypoxic stress. However, studies have shown that the physiological oxygen concentrations in several tissues are much lower than atmospheric (normoxic) conditions, and the oxygen supply is finely regulated in individual cell types. The gastrointestinal tract has been described to subsist in a state of physiologically low oxygen level and is thus depicted as a tissue in the state of constant low-grade inflammation. The intestinal epithelial cell layer plays a vital role in the immune response to inflammation and infections that occur within the intestinal tissue and is involved in many of the adaptation responses to hypoxic stress. This is especially relevant in the context of inflammatory disorders, such as inflammatory bowel disease (IBD). Therefore, this review aims to describe the intestinal epithelial cellular response to hypoxia and the consequences for host interactions with invading gastrointestinal bacterial pathogens.