Polymer grafted recyclable magnetic nanoparticles
Polymer grafted recyclable magnetic nanoparticles
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DOI：
10.1039/c4py01134a
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发表时间：
2015
影响因子：
4.6
通讯作者：
Lei Wang;M. Cole;Junting Li;Yang Zheng;Y. Chen;Kristen P. Miller;A. Decho;B. Benicewicz
中科院分区：
文献类型：
--
作者：
Lei Wang;M. Cole;Junting Li;Yang Zheng;Y. Chen;Kristen P. Miller;A. Decho;B. Benicewicz
这项工作报告了可回收磁性纳米颗粒、聚合物和抗生素的新组合，该组合在对抗细菌感染方面显示出更高的有效性。采用铁盐直接共沉淀策略生成饱和磁化强度为 59.5 emu g−1 的超顺磁性纳米粒子。应用二氧化硅涂层并用于稳定磁性纳米颗粒并为进一步功能化创建方便的平台。通过甲基丙烯酸的表面引发可逆加成断裂链转移（RAFT）聚合，在平均直径小至10 nm的磁性纳米粒子上制备了各种不同长度和密度的PMAA刷。使用磁铁进行抗菌测试后，将聚合物接枝的磁性纳米颗粒从水溶液中去除，从而避免了纳米对环境的污染。当与接枝 PMAA 的磁性纳米粒子物理结合时，抗生素（青霉素-G）对细菌（金黄色葡萄球菌和大肠杆菌）的生物活性显着增强。使用已重新装载青霉素-G 的回收磁性纳米颗粒保留了青霉素-纳米颗粒复合物的抑制活性。
This work reports on a new combination of recyclable magnetic nanoparticles, polymers and antibiotics that show increased effectiveness in combating bacterial infections. The direct-coprecipitation of iron salts strategy was used to generate superparamagnetic nanoparticles with a saturation magnetization of 59.5 emu g−1. A silica coating was applied and used to stabilize the magnetic nanoparticles and create a convenient platform for further functionalization. A variety of PMAA brushes with different lengths and densities were prepared on the magnetic nanoparticles with an average diameter size as small as 10 nm via surface-initiated reversible addition fragmentation chain transfer (RAFT) polymerization of methacrylic acid. The polymer grafted magnetic nanoparticles were removed from water solutions after antimicrobial testing using a magnet, thereby avoiding nano-based pollution of the environment. The bioactivity of an antibiotic (penicillin-G) over bacteria (Staphylococcus aureus and Escherichia coli) was significantly enhanced when physically bound to the PMAA grafted magnetic nanoparticles. The inhibition activity of the penicillin-nanoparticle complex was retained using recycled magnetic nanoparticles that had been reloaded with penicillin-G.