Remodeling of a collagenous tissue at fixed lengths
Remodeling of a collagenous tissue at fixed lengths
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DOI：
10.1115/1.2800858
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发表时间：
1999-12-01
影响因子：
1.7
通讯作者：
Humphrey, JD
中科院分区：
文献类型：
--
作者：
Humphrey, JD
成熟的组织通常能适应化学、机械或热环境的变化。例如，为了响应持续增加或减少的机械载荷，一些组织生长和重塑，以恢复应力或应变到其稳态状态。尽管之前的大多数工作都是针对组织生长的总体描述，但本文介绍了一种可能的细胞介导机制，通过这种机制，重塑可能发生在软结缔组织中——胶原沉积和降解的动力学是相似的，而不管它发生在什么身体结构上。所提出的理论框架适用于三维设置，但它是通过聚焦于单轴胶原组织的重塑，维持在一个固定的长度延长一段时间来说明。研究表明，这种重塑所期望的定性特征（例如，当重塑发生在延长的长度时，增加的顺应性和增加的无应力长度）很容易实现。然而，生长和重塑是复杂的现象，可能是通过多种互补机制完成的。因此，有必要确定其他候选机制，当然，还需要收集适合测试和完善可能理论的实验数据。
Mature tissues can often adapt to changes in their chemical, mechanical, or thermal environment. For example, in response to sustained increases or decreases in mechanical loads, some tissues grow and remodel so as to restore the stress or strain to its homeostatic state. Whereas most previous work addresses gross descriptors of tissue growth, this paper introduces a possible cell-mediated mechanism by which remodeling may occur in a soft connective tissue-that the kinetics of collagen deposition and degradation is similar regardless of the configuration of the body at which it occurs. The proposed theoretical framework applies to three-dimensional settings, but it is illustrated by focusing on the remodeling of a uniaxial collagenous tissue that is maintained at a fixed length for an extended period. It is shown that qualitative features expected of such remodeling (e.g., an increased compliance and increased stress-free length when remodeling occurs at an extended length) are easily realized. Growth and remodeling are complex phenomena, however, and are likely accomplished via multiple complementary mechanisms. There is a need, therefore, to identify other candidate mechanisms and, of course, to collect experimental data suitable for testing and refining the possible theories.