Role of HSPGs in Systemic Bacterial Infections.
Role of HSPGs in Systemic Bacterial Infections.
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DOI：
10.1007/978-1-0716-1398-6_46
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Park PW
中科院分区：
文献类型：
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作者：
Aquino RS;Hayashida K;Hayashida A;Park PW
Heparan sulfate proteoglycans (HSPGs) are at the forefront of host–microbe interactions. Cell surface HSPGs are thought to promote infection as attachment and internalization receptors for many bacterial pathogens and as soluble inhibitors of host immunity when released from the cell surface by ectodomain shedding. However, the importance of HSPG–pathogen interactions in vivo has yet to be clearly established. Here we describe several representative methods to study the role of HSPGs in systemic bacterial infections, such as bacteremia and sepsis. The overall experimental strategy is to use mouse models to establish the physiological significance of HSPGs, to determine the identity of HSPGs that specifically promote infection, and to define key structural features of HSPGs that enhance bacterial virulence in systemic infections.
