Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage.
Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage.
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DOI：
10.1155/2013/974358
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Hasson D
中科院分区：
文献类型：
--
作者：
Rodrigo R;Libuy M;Feliú F;Hasson D
心血管疾病是全世界死亡和发病的主要原因，其中高血压是主要危险因素。许多研究支持活性氧和氮在高血压的发病机制以及与缺血/再灌注相关的其他病理学中的作用。然而，在这些环境中，氧化应激相关生物标志物的验证仍然缺乏，这些生物标志物与其他生物标志物（如内皮祖细胞、内皮微粒和缺血修饰白蛋白）的新关联刚刚出现。氧化应激已被认为是原发性高血压早期的致病因素和治疗靶点。高血压和血压正常患者的收缩压和舒张压与血浆 F2-异前列烷水平呈正相关，与血浆总抗氧化能力呈负相关。体外循环心脏手术会引起与脂质过氧化和蛋白质羰基化增加相关的缺血/再灌注事件，这两种生物标志物与心脏组织的氧化损伤相关。抗氧化防御系统的增强应有助于改善由这种代谢损伤引起的功能和结构异常。然而，必须通过分析适当的氧化应激和/或亚硝化应激生物标志物来验证数据。
Cardiovascular diseases are a leading cause of mortality and morbidity worldwide, with hypertension being a major risk factor. Numerous studies support the contribution of reactive oxygen and nitrogen species in the pathogenesis of hypertension, as well as other pathologies associated with ischemia/reperfusion. However, the validation of oxidative stress-related biomarkers in these settings is still lacking and novel association of these biomarkers and other biomarkers such as endothelial progenitor cells, endothelial microparticles, and ischemia modified albumin, is just emerging. Oxidative stress has been suggested as a pathogenic factor and therapeutic target in early stages of essential hypertension. Systolic and diastolic blood pressure correlated positively with plasma F2-isoprostane levels and negatively with total antioxidant capacity of plasma in hypertensive and normotensive patients. Cardiac surgery with extracorporeal circulation causes an ischemia/reperfusion event associated with increased lipid peroxidation and protein carbonylation, two biomarkers associated with oxidative damage of cardiac tissue. An enhancement of the antioxidant defense system should contribute to ameliorating functional and structural abnormalities derived from this metabolic impairment. However, data have to be validated with the analysis of the appropriate oxidative stress and/or nitrosative stress biomarkers.
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影响因子：
37.8
作者：
Baldus, S;Heeschen, C;Hamm, CW
通讯作者：
Hamm, CW
影响因子：
4.8
作者：
ASAHI, M;FUJII, J;TANIGUCHI, N
通讯作者：
TANIGUCHI, N
DOI：
10.1111/j.1432-1033.1995.tb20419.x
发表时间：
1995-01-15
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
CHAN, B;DODSWORTH, N;HARRIS, R
通讯作者：
HARRIS, R
影响因子：
2.9
作者：
Chen W;Druhan LJ;Chen CA;Hemann C;Chen YR;Berka V;Tsai AL;Zweier JL
通讯作者：
Zweier JL
影响因子：
7.4
作者：
Buss, H;Chan, TP;Winterbourn, CC
通讯作者：
Winterbourn, CC