Image registration and analysis for quantitative myocardial perfusion: application to dynamic circular cardiac CT
Image registration and analysis for quantitative myocardial perfusion: application to dynamic circular cardiac CT
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DOI：
10.1088/0031-9155/56/18/010
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发表时间：
2011-09-21
影响因子：
3.5
通讯作者：
Grass, M.
中科院分区：
文献类型：
--
作者：
Isola, A. A.;Schmitt, H.;Grass, M.
具有快速旋转机架的大面积探测器计算机断层扫描系统能够进行容积动态心脏灌注研究。预先ECG触发的采集将数据采集限制在预定义的心脏相位，从而减少X射线剂量并限制运动伪影。即使在高度准确的前瞻性触发和稳定心率的情况下，每个心动周期采集和重建的心脏体积的空间未对准也可能由于周期与周期之间的小运动模式变化而发生。这些未对准降低了基于每个体素的心肌灌注参数的定量分析的准确性。这个问题的一个基于图像的解决方案是弹性的3D图像配准动态容积序列与可变对比度，因为它是在这方面的贡献。在覆盖大面积心肌组织的心脏体积的圆形锥形束CT重建之后，相对于所选择的参考体积对准完整系列。本文对配准过程和配准前后灌注分析的结果进行了定量评价。空间对齐导致三个不同的猪数据集的心肌灌注的定量改善。
Large area detector computed tomography systems with fast rotating gantries enable volumetric dynamic cardiac perfusion studies. Prospectively, ECG-triggered acquisitions limit the data acquisition to a predefined cardiac phase and thereby reduce x-ray dose and limit motion artefacts. Even in the case of highly accurate prospective triggering and stable heart rate, spatial misalignment of the cardiac volumes acquired and reconstructed per cardiac cycle may occur due to small motion pattern variations from cycle to cycle. These misalignments reduce the accuracy of the quantitative analysis of myocardial perfusion parameters on a per voxel basis. An image-based solution to this problem is elastic 3D image registration of dynamic volume sequences with variable contrast, as it is introduced in this contribution. After circular cone-beam CT reconstruction of cardiac volumes covering large areas of the myocardial tissue, the complete series is aligned with respect to a chosen reference volume. The results of the registration process and the perfusion analysis with and without registration are evaluated quantitatively in this paper. The spatial alignment leads to improved quantification of myocardial perfusion for three different pig data sets.