Lithium decreases turnover of arachidonate in several brain phospholipids
Lithium decreases turnover of arachidonate in several brain phospholipids
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DOI：
10.1016/s0304-3940(96)13264-x
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发表时间：
1996-12-20
影响因子：
2.5
通讯作者：
Rapaport, SI
中科院分区：
文献类型：
--
作者：
Chang, MCJ;Grange, E;Rapaport, SI
在清醒的大鼠长期锂治疗，放射性标记的棕榈酸酯和花生四烯酸酯，分别静脉输注后，在脑磷脂中的棕榈酸酯和花生四烯酸酯的掺入和营业额的体内率进行了测定。在被认为对人类有治疗作用的脑水平上，慢性锂使脑磷脂酰肌醇、磷脂酰胆碱和磷脂酰乙醇胺中花生四烯酸的周转率降低高达80%（P < 0.001）。相比之下，锂对棕榈酸酯周转的影响很小，仅导致磷脂酰胆碱周转减少26%（P < 0.01）。这些结果表明，锂的主要治疗作用是减少花生四烯酸的周转，可能是通过抑制参与信号转导的磷脂酶A（2）。这种作用可能继发于锂对磷酸肌醇循环的已知作用，即抑制肌醇单磷酸酶的活性。(C)1996爱思唯尔科学爱尔兰有限公司
In vivo rates of incorporation and turnover of palmitate and arachidonate in brain phospholipids were measured in awake rats treated chronically with lithium, following intravenous infusion of radiolabeled palmitate and arachidonate, respectively. Chronic lithium, at a brain level considered to be therapeutic in humans, decreased turnover of arachidonate within brain phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine by up to 80% (P < 0.001). In contrast, lithium had a minimal effect on turnover of palmitate, causing only a 26% reduction in turnover in phosphatidylcholine (P < 0.01). These results suggest that a major therapeutic effect of lithium is to reduce turnover specifically of arachidonate, possibly by inhibiting phospholipase A(2) involved in signal transduction. The effect may be secondary to the known action of lithium on the phosphoinositide cycle, by inhibiting the activity of inositol monophosphatase. (C) 1996 Elsevier Science Ireland Ltd.