Itk: the rheostat of the T cell response.
Itk: the rheostat of the T cell response.
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DOI：
10.1155/2011/297868
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Tsoukas CD
中科院分区：
文献类型：
--
作者：
Grasis JA;Tsoukas CD
非受体酪氨酸激酶ITK在TcR启动的信号转导中起关键作用，直接和显著地影响PLCγ1的调节和随后的钙离子动员。ITK还参与细胞骨架重组和细胞黏附的调节，而细胞黏附是产生T细胞反应所必需的。ITK的这些分子调控的功能性细胞结果使其成为T细胞发育和分化的重要中介。本文包括ITK的结构，导致ITK激活的信号参数，以及ITK在导致细胞功能结果的分子通路中的作用。这些因素的结合使人相信ITK作为调节器或变阻器，关键地微调T细胞的反应。
The nonreceptor tyrosine kinase Itk plays a key role in TCR-initiated signaling that directly and significantly affects the regulation of PLCγ1 and the consequent mobilization of Ca2+. Itk also participates in the regulation of cytoskeletal reorganization as well as cellular adhesion, which is necessary for a productive T cell response. The functional cellular outcome of these molecular regulations by Itk renders it an important mediator of T cell development and differentiation. This paper encompasses the structure of Itk, the signaling parameters leading to Itk activation, and Itk effects on molecular pathways resulting in functional cellular outcomes. The incorporation of these factors persuades one to believe that Itk serves as a modulator, or rheostat, critically fine-tuning the T cell response.