Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy.
Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy.
复制标题
肿瘤源性生长因子增加与恶性肿瘤体液高钙血症相关的肿瘤中的骨吸收。
DOI：
10.1126/science.6577602
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Mundy,GR
中科院分区：
文献类型：
--
作者：
Ibbotson,KJ;D'Souza,SM;Ng,KW;Osborne,CK;Niall,M;Martin,TJ;Mundy,GR
有证据表明，肿瘤衍生的转化生长因子是负责刺激骨吸收，并导致高钙血症的恶性肿瘤的动物肿瘤模型。从培养的肿瘤细胞收获的条件培养基和与高钙血症相关的可移植大鼠间质细胞瘤的肿瘤提取物均含有具有肿瘤衍生的转化生长因子的化学特征的大分子骨吸收因子。
Evidence is presented that a tumor-derived transforming growth factor is responsible for stimulating bone resorption and causing hypercalcemia in an animal tumor model of the hypercalcemia of malignancy. Both conditioned medium harvested from cultured tumor cells and tumor extracts of the transplantable rat Leydig cell tumor associated with hypercalcemia contained a macromolecular bone resorbing factor with the chemical characteristics of a tumor-derived transforming growth factor.